Mendeleev Communications

, volume 31 , issue 5 , pages 664-666

Anticancer activity of novel 3-azaxanthenes

Lyudmila Kibardina ¹

Alexey V Trifonov ¹

Alexey Dobrynin ¹

Michail A. Pudovik ¹

Alexander R. Burilov ¹

A. D. Voloshina ¹

Anna G Strelnik ¹

Almir S. Gazizov ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

A. E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences, 420088 Kazan, Russian Federation

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Kazan Scientific Center of the Russian Academy of Sciences

Publication type: Journal Article

Publication date: 2021-09-01

OOO Zhurnal "Mendeleevskie Soobshcheniya"

Mendeleev Communications

scimago Q3

wos Q3

SJR: 0.305

CiteScore: 3.0

Impact factor: 1.7

ISSN: 09599436, 1364551X

DOI: 10.1016/j.mencom.2021.09.024

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General Chemistry

Abstract

Novel 3-azaxanthenes have been synthesized via acid-catalyzed one-pot Friedel–Crafts reaction of pyridoxal/pyridoxal-5'-phosphate with naphthols followed by dehydration of the intermediate bis(2-hydroxyaryl)-(pyridin-4-yl)methane derivatives. The cytotoxicity of the obtained 3-azaxanthenes against M-HeLa and HuTu-80 tumor cell lines is comparable to that of tamoxifen, whereas the cytotoxicity against normal cell line is absent in the tested concentrations range, which makes this class of compounds interesting for further studies.

Found

2 citations

Gazizov Almir

🥼

DSc in Chemistry

159 publications, 911 citations, 23 reviews

h-index: 14

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Heterocyclic compounds

Organic Chemistry

Organophosphorus chemistry

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Kibardina L. et al. Anticancer activity of novel 3-azaxanthenes // Mendeleev Communications. 2021. Vol. 31. No. 5. pp. 664-666.

GOST all authors (up to 50) Copy

Kibardina L., Trifonov A. V., Dobrynin A., Pudovik M. A., Burilov A. R., Voloshina A. D., Strelnik A. G., Gazizov A. S. Anticancer activity of novel 3-azaxanthenes // Mendeleev Communications. 2021. Vol. 31. No. 5. pp. 664-666.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.mencom.2021.09.024

UR - https://doi.org/10.1016/j.mencom.2021.09.024

TI - Anticancer activity of novel 3-azaxanthenes

T2 - Mendeleev Communications

AU - Kibardina, Lyudmila

AU - Trifonov, Alexey V

AU - Dobrynin, Alexey

AU - Pudovik, Michail A.

AU - Burilov, Alexander R.

AU - Voloshina, A. D.

AU - Strelnik, Anna G

AU - Gazizov, Almir S.

PY - 2021

DA - 2021/09/01

PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"

SP - 664-666

IS - 5

VL - 31

SN - 0959-9436

SN - 1364-551X

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2021_Kibardina,

author = {Lyudmila Kibardina and Alexey V Trifonov and Alexey Dobrynin and Michail A. Pudovik and Alexander R. Burilov and A. D. Voloshina and Anna G Strelnik and Almir S. Gazizov},

title = {Anticancer activity of novel 3-azaxanthenes},

journal = {Mendeleev Communications},

year = {2021},

volume = {31},

publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},

month = {sep},

url = {https://doi.org/10.1016/j.mencom.2021.09.024},

number = {5},

pages = {664--666},

doi = {10.1016/j.mencom.2021.09.024}

}

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MLA Copy

Kibardina, Lyudmila, et al. “Anticancer activity of novel 3-azaxanthenes.” Mendeleev Communications, vol. 31, no. 5, Sep. 2021, pp. 664-666. https://doi.org/10.1016/j.mencom.2021.09.024.