Anticancer activity of new benzofuroxan–imidazolone hybrids
Elena Chugunova
1
,
Almir S. Gazizov
1
,
A. D. Voloshina
1
,
Anna P Lyubina
1
,
Atyana A Melnikova
2
,
Alena I Tulesinova
2
,
Nurlybek A Akhatayev
3
,
3
Korkyt Ata Kyzylorda University, 120014 Kyzylorda, Republic of Kazakhstan
|
Publication type: Journal Article
Publication date: 2021-11-01
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
Novel hybrid compounds containing both benzofuroxan and 1 H -imidazol-2(3 H )-one moieties were synthesized by an S N Ar reaction between 7-chloro-4,6-dinitrobenzofuroxan and imidazol-2-ones, with the only C 4 regioisomer having been formed. Cytotoxic effects of parent and obtained compounds were estimated on human cancer and normal cells, while two of imidazolones showed higher cytotoxicity in relation to the M-HeLa cancer line compared to the hybrid products. In relation to the normal liver cell line Chang, the tested compounds were found to be non-toxic and can be promising for further development of anticancer agents.
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Chugunova E. et al. Anticancer activity of new benzofuroxan–imidazolone hybrids // Mendeleev Communications. 2021. Vol. 31. No. 6. pp. 865-866.
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Chugunova E., Smolobochkin A. V., Gazizov A. S., Burilov A. R., Voloshina A. D., Lyubina A. P., Gumerova S., Melnikova A. A., Tulesinova A. I., Akylbekov N., Akhatayev N. A., Syakaev V. V. Anticancer activity of new benzofuroxan–imidazolone hybrids // Mendeleev Communications. 2021. Vol. 31. No. 6. pp. 865-866.
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TY - JOUR
DO - 10.1016/j.mencom.2021.11.032
UR - https://doi.org/10.1016/j.mencom.2021.11.032
TI - Anticancer activity of new benzofuroxan–imidazolone hybrids
T2 - Mendeleev Communications
AU - Chugunova, Elena
AU - Smolobochkin, Andrey V.
AU - Gazizov, Almir S.
AU - Burilov, Alexander R.
AU - Voloshina, A. D.
AU - Lyubina, Anna P
AU - Gumerova, Syumbelya
AU - Melnikova, Atyana A
AU - Tulesinova, Alena I
AU - Akylbekov, Nurgali
AU - Akhatayev, Nurlybek A
AU - Syakaev, Victor V.
PY - 2021
DA - 2021/11/01
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 865-866
IS - 6
VL - 31
SN - 0959-9436
SN - 1364-551X
ER -
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@article{2021_Chugunova,
author = {Elena Chugunova and Andrey V. Smolobochkin and Almir S. Gazizov and Alexander R. Burilov and A. D. Voloshina and Anna P Lyubina and Syumbelya Gumerova and Atyana A Melnikova and Alena I Tulesinova and Nurgali Akylbekov and Nurlybek A Akhatayev and Victor V. Syakaev},
title = {Anticancer activity of new benzofuroxan–imidazolone hybrids},
journal = {Mendeleev Communications},
year = {2021},
volume = {31},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {nov},
url = {https://doi.org/10.1016/j.mencom.2021.11.032},
number = {6},
pages = {865--866},
doi = {10.1016/j.mencom.2021.11.032}
}
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MLA
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Chugunova, Elena, et al. “Anticancer activity of new benzofuroxan–imidazolone hybrids.” Mendeleev Communications, vol. 31, no. 6, Nov. 2021, pp. 865-866. https://doi.org/10.1016/j.mencom.2021.11.032.
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