volume 32 issue 1 pages 120-122

A comparative evaluation of monomethoxy substituted o-diarylazoles as antiproliferative microtubule destabilizing agents

Publication typeJournal Article
Publication date2022-01-01
scimago Q3
wos Q3
SJR0.305
CiteScore3.0
Impact factor1.7
ISSN09599436, 1364551X
General Chemistry
Abstract
Monomethoxy substituted o -diarylazoles with isoxazole, triazole, pyrazole, or pyrrole linkers were synthesized and evaluated for antimitotic antitubulin activity in a sea urchin embryo model. Structure–activity relationship study revealed that only isoxazole heterocycle together with the unsubstituted phenyl ring next to the heteroatom endowed the molecule with appropriate configuration to exhibit antiproliferative effect by microtubule destabilizing mode of action.
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Silyanova E. A. et al. A comparative evaluation of monomethoxy substituted o-diarylazoles as antiproliferative microtubule destabilizing agents // Mendeleev Communications. 2022. Vol. 32. No. 1. pp. 120-122.
GOST all authors (up to 50) Copy
Silyanova E. A., Ushkarov V. I., Samet A. V., Maksimenko A., Koblov I. A., Kislyi V. P., Semenova M., Semenov V. A comparative evaluation of monomethoxy substituted o-diarylazoles as antiproliferative microtubule destabilizing agents // Mendeleev Communications. 2022. Vol. 32. No. 1. pp. 120-122.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.mencom.2022.01.039
UR - https://doi.org/10.1016/j.mencom.2022.01.039
TI - A comparative evaluation of monomethoxy substituted o-diarylazoles as antiproliferative microtubule destabilizing agents
T2 - Mendeleev Communications
AU - Silyanova, Eugenia A
AU - Ushkarov, Vladimir I
AU - Samet, Alexander V.
AU - Maksimenko, Anna
AU - Koblov, Ivan A
AU - Kislyi, Victor P.
AU - Semenova, Marina
AU - Semenov, Victor
PY - 2022
DA - 2022/01/01
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 120-122
IS - 1
VL - 32
SN - 0959-9436
SN - 1364-551X
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2022_Silyanova,
author = {Eugenia A Silyanova and Vladimir I Ushkarov and Alexander V. Samet and Anna Maksimenko and Ivan A Koblov and Victor P. Kislyi and Marina Semenova and Victor Semenov},
title = {A comparative evaluation of monomethoxy substituted o-diarylazoles as antiproliferative microtubule destabilizing agents},
journal = {Mendeleev Communications},
year = {2022},
volume = {32},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {jan},
url = {https://doi.org/10.1016/j.mencom.2022.01.039},
number = {1},
pages = {120--122},
doi = {10.1016/j.mencom.2022.01.039}
}
MLA
Cite this
MLA Copy
Silyanova, Eugenia A., et al. “A comparative evaluation of monomethoxy substituted o-diarylazoles as antiproliferative microtubule destabilizing agents.” Mendeleev Communications, vol. 32, no. 1, Jan. 2022, pp. 120-122. https://doi.org/10.1016/j.mencom.2022.01.039.