Mendeleev Communications
,  volume 32 ,  issue 6 ,  pages 747-749

Synthesis of novel glutarimide derivatives via the Ugi multicomponent reaction: affinity towards the E3 ubiquitin ligase substrate receptor Cereblon

Publication type: Journal Article
Publication date: 2022-11-28
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
The glutarimide moiety, common in many immuno-modulatory drugs, was decorated with lactam and diamide side chains via two variants of the Ugi reaction, namely, with isocyanide, aldehyde and acid or with isocyanide and oxo acid. The resulting diastereomerically pure compounds were evaluated for their affinity towards the E3 ubiquitin ligase substrate receptor Cereblon.
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Barkhatova D. et al. Synthesis of novel glutarimide derivatives via the Ugi multicomponent reaction: affinity towards the E3 ubiquitin ligase substrate receptor Cereblon // Mendeleev Communications. 2022. Vol. 32. No. 6. pp. 747-749.
GOST all authors (up to 50) Copy
Barkhatova D., Zhukovsky D., Heim C., Maiwald S., Hartmann M. D., Krasavin M. Synthesis of novel glutarimide derivatives via the Ugi multicomponent reaction: affinity towards the E3 ubiquitin ligase substrate receptor Cereblon // Mendeleev Communications. 2022. Vol. 32. No. 6. pp. 747-749.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.mencom.2022.11.013
UR - https://doi.org/10.1016/j.mencom.2022.11.013
TI - Synthesis of novel glutarimide derivatives via the Ugi multicomponent reaction: affinity towards the E3 ubiquitin ligase substrate receptor Cereblon
T2 - Mendeleev Communications
AU - Barkhatova, Darina
AU - Zhukovsky, Daniil
AU - Heim, Christopher
AU - Maiwald, Samuel
AU - Hartmann, Marcus D.
AU - Krasavin, Mikhail
PY - 2022
DA - 2022/11/28
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 747-749
IS - 6
VL - 32
SN - 0959-9436
SN - 1364-551X
ER -
BibTex |
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BibTex (up to 50 authors) Copy
@article{2022_Barkhatova,
author = {Darina Barkhatova and Daniil Zhukovsky and Christopher Heim and Samuel Maiwald and Marcus D. Hartmann and Mikhail Krasavin},
title = {Synthesis of novel glutarimide derivatives via the Ugi multicomponent reaction: affinity towards the E3 ubiquitin ligase substrate receptor Cereblon},
journal = {Mendeleev Communications},
year = {2022},
volume = {32},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {nov},
url = {https://doi.org/10.1016/j.mencom.2022.11.013},
number = {6},
pages = {747--749},
doi = {10.1016/j.mencom.2022.11.013}
}
MLA
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MLA Copy
Barkhatova, Darina, et al. “Synthesis of novel glutarimide derivatives via the Ugi multicomponent reaction: affinity towards the E3 ubiquitin ligase substrate receptor Cereblon.” Mendeleev Communications, vol. 32, no. 6, Nov. 2022, pp. 747-749. https://doi.org/10.1016/j.mencom.2022.11.013.