Mendeleev Communications
,  volume 33 ,  issue 1 ,  pages 73-76

2-Amino-4-(aminomethyl)thiazole-based derivatives as potential antitumor agents: design, synthesis, cytotoxicity and apoptosis inducing activities

Publication type: Journal Article
Publication date: 2023-01-01
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
Novel 2-amino-4-(aminomethyl)thiazole derivatives were designed and synthesized by a facile method including the Hantzsch construction of thiazole core followed by amidation and nucleophilic substitution steps. Bioassay results showed that 4-(tert-butyl)-N-[4-(piperazin-1-ylmethyl)thiazol-2-yl]-benzamide and 4-(tert-butyl)-N-{4-[(4-piperidinopiperidin-1-yl)methyl]thiazol-2-yl}benzamide possessed similar activities compared with 5-fluorouracil. The 4-piperidino-piperidin-1-yl-containing derivative also suppressed proliferation of cultured tumor cells by inducing apoptosis.
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Liao M., Huang D. L., Cheng Y. X. 2-Amino-4-(aminomethyl)thiazole-based derivatives as potential antitumor agents: design, synthesis, cytotoxicity and apoptosis inducing activities // Mendeleev Communications. 2023. Vol. 33. No. 1. pp. 73-76.
GOST all authors (up to 50) Copy
Liao M., Huang D. L., Cheng Y. X. 2-Amino-4-(aminomethyl)thiazole-based derivatives as potential antitumor agents: design, synthesis, cytotoxicity and apoptosis inducing activities // Mendeleev Communications. 2023. Vol. 33. No. 1. pp. 73-76.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.mencom.2023.01.023
UR - https://doi.org/10.1016/j.mencom.2023.01.023
TI - 2-Amino-4-(aminomethyl)thiazole-based derivatives as potential antitumor agents: design, synthesis, cytotoxicity and apoptosis inducing activities
T2 - Mendeleev Communications
AU - Liao, Min
AU - Huang, Dan Ling
AU - Cheng, Yong Xian
PY - 2023
DA - 2023/01/01
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 73-76
IS - 1
VL - 33
SN - 0959-9436
SN - 1364-551X
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Liao,
author = {Min Liao and Dan Ling Huang and Yong Xian Cheng},
title = {2-Amino-4-(aminomethyl)thiazole-based derivatives as potential antitumor agents: design, synthesis, cytotoxicity and apoptosis inducing activities},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {jan},
url = {https://doi.org/10.1016/j.mencom.2023.01.023},
number = {1},
pages = {73--76},
doi = {10.1016/j.mencom.2023.01.023}
}
MLA
Cite this
MLA Copy
Liao, Min, et al. “2-Amino-4-(aminomethyl)thiazole-based derivatives as potential antitumor agents: design, synthesis, cytotoxicity and apoptosis inducing activities.” Mendeleev Communications, vol. 33, no. 1, Jan. 2023, pp. 73-76. https://doi.org/10.1016/j.mencom.2023.01.023.