Mendeleev Communications

, volume 33 , issue 2 , pages 237-239

Synthesis and cytotoxicity of 7,8-dihalopyrido[1,2-a]benzimidazole-6,9-dione and its 1,2,3,4-tetrahydro analogue

Roman S Begunov ¹

Yulia R. Aleksandrova ²

Ekaterina Yandulova ²

N S Nikolaeva ²

Margarita E. Neganova ²

Hide authors affiliations Show authors affiliations: 2 affiliations

P. G. Demidov Yaroslavl State University, 150003 Yaroslavl, Russian Federation |

Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Russian Federation

Institute of Physiologically Active Compounds of the Russian Academy of Science

Federal Research Center of Problem of Chemical Physics and Medicinal Chemistry RAS

Publication type: Journal Article

Publication date: 2023-03-01

OOO Zhurnal "Mendeleevskie Soobshcheniya"

Mendeleev Communications

scimago Q3

wos Q3

SJR: 0.305

CiteScore: 3.0

Impact factor: 1.7

ISSN: 09599436, 1364551X

DOI: 10.1016/j.mencom.2023.02.028

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General Chemistry

Abstract

An efficient synthesis of 8-bromo-7-chloropyrido[1,2-a]-benzimidazole-6,9-dione and its 1,2,3,4-tetrahydro analogue from N-(4-chloro-2-nitrophenyl)pyridinium chloride has been accomplished. The study for antitumour activity against cancer cell lines such as A549, SH-SY5Y, Hep-2, HeLa and MCF-7 revealed that the cytotoxic effect of the compounds obtained was several times higher than that of Mitomycin C.

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Begunov R. S. et al. Synthesis and cytotoxicity of 7,8-dihalopyrido[1,2-a]benzimidazole-6,9-dione and its 1,2,3,4-tetrahydro analogue // Mendeleev Communications. 2023. Vol. 33. No. 2. pp. 237-239.

GOST all authors (up to 50) Copy

Begunov R. S., Aleksandrova Y. R., Yandulova E., Nikolaeva N. S., E. Neganova M. Synthesis and cytotoxicity of 7,8-dihalopyrido[1,2-a]benzimidazole-6,9-dione and its 1,2,3,4-tetrahydro analogue // Mendeleev Communications. 2023. Vol. 33. No. 2. pp. 237-239.

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RIS Copy

TY - JOUR

DO - 10.1016/j.mencom.2023.02.028

UR - https://doi.org/10.1016/j.mencom.2023.02.028

TI - Synthesis and cytotoxicity of 7,8-dihalopyrido[1,2-a]benzimidazole-6,9-dione and its 1,2,3,4-tetrahydro analogue

T2 - Mendeleev Communications

AU - Begunov, Roman S

AU - Aleksandrova, Yulia R.

AU - Yandulova, Ekaterina

AU - Nikolaeva, N S

AU - E. Neganova, Margarita

PY - 2023

DA - 2023/03/01

PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"

SP - 237-239

IS - 2

VL - 33

SN - 0959-9436

SN - 1364-551X

ER -

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@article{2023_Begunov,

author = {Roman S Begunov and Yulia R. Aleksandrova and Ekaterina Yandulova and N S Nikolaeva and Margarita E. Neganova},

title = {Synthesis and cytotoxicity of 7,8-dihalopyrido[1,2-a]benzimidazole-6,9-dione and its 1,2,3,4-tetrahydro analogue},

journal = {Mendeleev Communications},

year = {2023},

volume = {33},

publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},

month = {mar},

url = {https://doi.org/10.1016/j.mencom.2023.02.028},

number = {2},

pages = {237--239},

doi = {10.1016/j.mencom.2023.02.028}

}

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Begunov, Roman S., et al. “Synthesis and cytotoxicity of 7,8-dihalopyrido[1,2-a]benzimidazole-6,9-dione and its 1,2,3,4-tetrahydro analogue.” Mendeleev Communications, vol. 33, no. 2, Mar. 2023, pp. 237-239. https://doi.org/10.1016/j.mencom.2023.02.028.