Mendeleev Communications
,  volume 33 ,  issue 4 ,  pages 537-538

New N1-(4-aryloxybenzyl)uracils containing N3-positioned 4-(trimethyleneoxy)benzoic acid moiety, and study of their antiviral activity against SARS-CoV-2 and influenza virus

Publication type: Journal Article
Publication date: 2023-07-17
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
New title uracil derivatives, 4-{3-[2,6-dioxo-3-(4-aryl-oxybenzyl)-3,6-dihydropyrimidin-1(2H)-yl]propoxy}benzoic acids and their butoxy homologues, were obtained in three steps using 2,4-bis(trimethylsilyloxy)pyrimidine, 4-aryloxy-benzyl bromides and methyl 4-(ω-bromoalkoxy)benzoates as the key reactants. The compounds were studied as inhibitors of H1N1 influenza virus and SARS-CoV-2 R replication in MDCK and Vero E6 cell cultures, respectively, which revealed that the tested compounds had high levels of anti-SARS-CoV-2 activity.
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GOST Copy
Novikov M. S. et al. New N1-(4-aryloxybenzyl)uracils containing N3-positioned 4-(trimethyleneoxy)benzoic acid moiety, and study of their antiviral activity against SARS-CoV-2 and influenza virus // Mendeleev Communications. 2023. Vol. 33. No. 4. pp. 537-538.
GOST all authors (up to 50) Copy
Novikov M. S., Paramonova M. P., Kirillov I. M., Smirnova O., Khandazhinskaya A., Chizhov A. O., Kochetkov S. N., Ivanov A., Fedyakina I. F. New N1-(4-aryloxybenzyl)uracils containing N3-positioned 4-(trimethyleneoxy)benzoic acid moiety, and study of their antiviral activity against SARS-CoV-2 and influenza virus // Mendeleev Communications. 2023. Vol. 33. No. 4. pp. 537-538.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.mencom.2023.06.031
UR - https://doi.org/10.1016/j.mencom.2023.06.031
TI - New N1-(4-aryloxybenzyl)uracils containing N3-positioned 4-(trimethyleneoxy)benzoic acid moiety, and study of their antiviral activity against SARS-CoV-2 and influenza virus
T2 - Mendeleev Communications
AU - Novikov, Mikhail S.
AU - Paramonova, Maria P
AU - Kirillov, Ilia M.
AU - Smirnova, Olga
AU - Khandazhinskaya, Anastasia
AU - Chizhov, A. O.
AU - Kochetkov, Sergey N.
AU - Ivanov, Alexander
AU - Fedyakina, Irina F.
PY - 2023
DA - 2023/07/17
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 537-538
IS - 4
VL - 33
SN - 0959-9436
SN - 1364-551X
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Novikov,
author = {Mikhail S. Novikov and Maria P Paramonova and Ilia M. Kirillov and Olga Smirnova and Anastasia Khandazhinskaya and A. O. Chizhov and Sergey N. Kochetkov and Alexander Ivanov and Irina F. Fedyakina},
title = {New N1-(4-aryloxybenzyl)uracils containing N3-positioned 4-(trimethyleneoxy)benzoic acid moiety, and study of their antiviral activity against SARS-CoV-2 and influenza virus},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {jul},
url = {https://doi.org/10.1016/j.mencom.2023.06.031},
number = {4},
pages = {537--538},
doi = {10.1016/j.mencom.2023.06.031}
}
MLA
Cite this
MLA Copy
Novikov, Mikhail S., et al. “New N1-(4-aryloxybenzyl)uracils containing N3-positioned 4-(trimethyleneoxy)benzoic acid moiety, and study of their antiviral activity against SARS-CoV-2 and influenza virus.” Mendeleev Communications, vol. 33, no. 4, Jul. 2023, pp. 537-538. https://doi.org/10.1016/j.mencom.2023.06.031.