Mendeleev Communications
,  том 33 ,  издание 4 ,  страницы 543-545

Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies

Тип публикации: Journal Article
Дата публикации: 2023-07-17
scimago Q3
wos Q3
БС1
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Краткое описание
3-Arylidene-1-(2,6-dichlorophenyl)indolones and in particular their 5-methylaminosulfonyl derivatives efficiently inhibit α-glucosidase enzyme. The results are corroborated by in silico docking studies which show the binding of aminosulfonyl derivatives to be more favorable due to additional hydrogen bonding. The most active compound of the series shows the IC50 of 6.19 μm.
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Nguyen G. V. et al. Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies // Mendeleev Communications. 2023. Vol. 33. No. 4. pp. 543-545.
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Nguyen G. V., Dang H. T., Nguyen L. D., Nguyen H. V., Le H. T. T., Nguyen H. H., Nguyen A. V., Nguyen Y. H., Van-Ha N., Do H. Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies // Mendeleev Communications. 2023. Vol. 33. No. 4. pp. 543-545.
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TY - JOUR
DO - 10.1016/j.mencom.2023.06.033
UR - https://doi.org/10.1016/j.mencom.2023.06.033
TI - Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies
T2 - Mendeleev Communications
AU - Nguyen, Giang V.
AU - Dang, Hoang T
AU - Nguyen, Luyen D.
AU - Nguyen, Hai V.
AU - Le, Huong Thi Thu
AU - Nguyen, Huy H.N.
AU - Nguyen, An V.
AU - Nguyen, Yen H
AU - Van-Ha, Nguyen
AU - Do, Huy-Hoang
PY - 2023
DA - 2023/07/17
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 543-545
IS - 4
VL - 33
SN - 0959-9436
SN - 1364-551X
ER -
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@article{2023_Nguyen,
author = {Giang V. Nguyen and Hoang T Dang and Luyen D. Nguyen and Hai V. Nguyen and Huong Thi Thu Le and Huy H.N. Nguyen and An V. Nguyen and Yen H Nguyen and Nguyen Van-Ha and Huy-Hoang Do},
title = {Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {jul},
url = {https://doi.org/10.1016/j.mencom.2023.06.033},
number = {4},
pages = {543--545},
doi = {10.1016/j.mencom.2023.06.033}
}
MLA
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Nguyen, Giang V., et al. “Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies.” Mendeleev Communications, vol. 33, no. 4, Jul. 2023, pp. 543-545. https://doi.org/10.1016/j.mencom.2023.06.033.
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