Mendeleev Communications
,  volume 33 ,  issue 4 ,  pages 543-545

Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies

Giang V. Nguyen 1
, 
Hoang T Dang 1
, 
Luyen D. Nguyen 1
, 
Hai V. Nguyen 1
, 
Huong Thi Thu Le 1
, 
Huy H.N. Nguyen 2
, 
An V. Nguyen 2
, 
Yen H Nguyen 3
, 
Nguyen Van-Ha 3
, 
Huy-Hoang Do 3
1
 
2
 
Nguyen Gia Thieu High School, Long Bien, Gia Lam, 11811 Hanoi, Vietnam | 
3
 
Publication type: Journal Article
Publication date: 2023-07-17
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
3-Arylidene-1-(2,6-dichlorophenyl)indolones and in particular their 5-methylaminosulfonyl derivatives efficiently inhibit α-glucosidase enzyme. The results are corroborated by in silico docking studies which show the binding of aminosulfonyl derivatives to be more favorable due to additional hydrogen bonding. The most active compound of the series shows the IC50 of 6.19 μm.
Found 
Found 

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GOST Copy
Nguyen G. V. et al. Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies // Mendeleev Communications. 2023. Vol. 33. No. 4. pp. 543-545.
GOST all authors (up to 50) Copy
Nguyen G. V., Dang H. T., Nguyen L. D., Nguyen H. V., Le H. T. T., Nguyen H. H., Nguyen A. V., Nguyen Y. H., Van-Ha N., Do H. Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies // Mendeleev Communications. 2023. Vol. 33. No. 4. pp. 543-545.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.mencom.2023.06.033
UR - https://doi.org/10.1016/j.mencom.2023.06.033
TI - Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies
T2 - Mendeleev Communications
AU - Nguyen, Giang V.
AU - Dang, Hoang T
AU - Nguyen, Luyen D.
AU - Nguyen, Hai V.
AU - Le, Huong Thi Thu
AU - Nguyen, Huy H.N.
AU - Nguyen, An V.
AU - Nguyen, Yen H
AU - Van-Ha, Nguyen
AU - Do, Huy-Hoang
PY - 2023
DA - 2023/07/17
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 543-545
IS - 4
VL - 33
SN - 0959-9436
SN - 1364-551X
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Nguyen,
author = {Giang V. Nguyen and Hoang T Dang and Luyen D. Nguyen and Hai V. Nguyen and Huong Thi Thu Le and Huy H.N. Nguyen and An V. Nguyen and Yen H Nguyen and Nguyen Van-Ha and Huy-Hoang Do},
title = {Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {jul},
url = {https://doi.org/10.1016/j.mencom.2023.06.033},
number = {4},
pages = {543--545},
doi = {10.1016/j.mencom.2023.06.033}
}
MLA
Cite this
MLA Copy
Nguyen, Giang V., et al. “Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies.” Mendeleev Communications, vol. 33, no. 4, Jul. 2023, pp. 543-545. https://doi.org/10.1016/j.mencom.2023.06.033.
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