Microwave-assisted synthesis of 5-aryl-3-hydroxy-2-oxindole derivatives and evaluation of their antiglaucomic activity
Alexander M. Efremov
1, 2
,
Denis A Babkov
3
,
Olga Beznos
4
,
E.V. Sokolova
3
,
А. А. Спасов
3
,
Vladimir N. Ivanov
1
,
Alexander V Kurkin
1
,
N A Lozinskaya
1
1
4
Helmholtz National Medical Centre of Eye Diseases, 105062 Moscow, Russian Federation
|
Publication type: Journal Article
Publication date: 2023-07-17
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
A set of new 5-aryl-3-hydroxy-2-oxindoles was synthesized by decarboxylative condensation of the corresponding 5-aryl-substituted isatins with malonic or cyanoacetic acids under microwave irradiation. The antiglaucomic activity of the obtained compounds was evaluated. The most water soluble compounds can reduce the intraocular pressure (IOP) up to 2 Torr.
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Efremov A. M. et al. Microwave-assisted synthesis of 5-aryl-3-hydroxy-2-oxindole derivatives and evaluation of their antiglaucomic activity // Mendeleev Communications. 2023. Vol. 33. No. 4. pp. 550-552.
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Efremov A. M., Babkov D. A., Beznos O., Sokolova E., Спасов А. А., Ivanov V. N., Kurkin A. V., Chesnokova N., Lozinskaya N. A. Microwave-assisted synthesis of 5-aryl-3-hydroxy-2-oxindole derivatives and evaluation of their antiglaucomic activity // Mendeleev Communications. 2023. Vol. 33. No. 4. pp. 550-552.
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TY - JOUR
DO - 10.1016/j.mencom.2023.06.035
UR - https://doi.org/10.1016/j.mencom.2023.06.035
TI - Microwave-assisted synthesis of 5-aryl-3-hydroxy-2-oxindole derivatives and evaluation of their antiglaucomic activity
T2 - Mendeleev Communications
AU - Efremov, Alexander M.
AU - Babkov, Denis A
AU - Beznos, Olga
AU - Sokolova, E.V.
AU - Спасов, А. А.
AU - Ivanov, Vladimir N.
AU - Kurkin, Alexander V
AU - Chesnokova, Natalia
AU - Lozinskaya, N A
PY - 2023
DA - 2023/07/17
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 550-552
IS - 4
VL - 33
SN - 0959-9436
SN - 1364-551X
ER -
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BibTex (up to 50 authors)
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@article{2023_Efremov,
author = {Alexander M. Efremov and Denis A Babkov and Olga Beznos and E.V. Sokolova and А. А. Спасов and Vladimir N. Ivanov and Alexander V Kurkin and Natalia Chesnokova and N A Lozinskaya},
title = {Microwave-assisted synthesis of 5-aryl-3-hydroxy-2-oxindole derivatives and evaluation of their antiglaucomic activity},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {jul},
url = {https://doi.org/10.1016/j.mencom.2023.06.035},
number = {4},
pages = {550--552},
doi = {10.1016/j.mencom.2023.06.035}
}
Cite this
MLA
Copy
Efremov, Alexander M., et al. “Microwave-assisted synthesis of 5-aryl-3-hydroxy-2-oxindole derivatives and evaluation of their antiglaucomic activity.” Mendeleev Communications, vol. 33, no. 4, Jul. 2023, pp. 550-552. https://doi.org/10.1016/j.mencom.2023.06.035.