Two-step synthesis of indeno[1,2-b]furazanopyrazines through combination of the SNH and Heck reactions
Yuriy A Kvashnin
1, 2
,
Danila V Belyaev
1, 3
,
Marina A Ezhikova
1
,
Gennady L Rusinov
1, 2
,
Egor V. Verbitskiy
1, 2
,
Valery Charushin
1, 2
2
Publication type: Journal Article
Publication date: 2023-11-29
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
Enamines generated in situ from aliphatic amines and acetone react with 5-(2-bromophenyl)furazano[3,4-b]pyrazines via the nucleophilic substitution of hydrogen atom of the pyrazine ring. A representative of 9H-indeno[1,2-b]furazanopyrazin-9-ylidene ring system has been accessed by exploiting the intramolecular Heck cyclization of the obtained SNH-product. Several compounds derived from the SNH reaction, namely, N-alkyl-1-[6-(2-bromophenyl)furazano[ 3,4-b]pyrazin-5-yl]prop-1-en-2-amines, proved to exhibit a bacteriostatic activity in vitro against Mycobacterium tuberculosis H37Rv
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Total citations:
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Citations from 2025:
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Kvashnin Y. A. et al. Two-step synthesis of indeno[1,2-b]furazanopyrazines through combination of the SNH and Heck reactions // Mendeleev Communications. 2023. Vol. 33. No. 6. pp. 753-755.
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Kvashnin Y. A., Belyaev D. V., Kodess M. I., Ezhikova M. A., Rusinov G. L., Verbitskiy E. V., Charushin V. Two-step synthesis of indeno[1,2-b]furazanopyrazines through combination of the SNH and Heck reactions // Mendeleev Communications. 2023. Vol. 33. No. 6. pp. 753-755.
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TY - JOUR
DO - 10.1016/j.mencom.2023.10.004
UR - https://doi.org/10.1016/j.mencom.2023.10.004
TI - Two-step synthesis of indeno[1,2-b]furazanopyrazines through combination of the SNH and Heck reactions
T2 - Mendeleev Communications
AU - Kvashnin, Yuriy A
AU - Belyaev, Danila V
AU - Kodess, Mikhail I.
AU - Ezhikova, Marina A
AU - Rusinov, Gennady L
AU - Verbitskiy, Egor V.
AU - Charushin, Valery
PY - 2023
DA - 2023/11/29
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 753-755
IS - 6
VL - 33
SN - 0959-9436
SN - 1364-551X
ER -
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BibTex (up to 50 authors)
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@article{2023_Kvashnin,
author = {Yuriy A Kvashnin and Danila V Belyaev and Mikhail I. Kodess and Marina A Ezhikova and Gennady L Rusinov and Egor V. Verbitskiy and Valery Charushin},
title = {Two-step synthesis of indeno[1,2-b]furazanopyrazines through combination of the SNH and Heck reactions},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {nov},
url = {https://doi.org/10.1016/j.mencom.2023.10.004},
number = {6},
pages = {753--755},
doi = {10.1016/j.mencom.2023.10.004}
}
Cite this
MLA
Copy
Kvashnin, Yuriy A., et al. “Two-step synthesis of indeno[1,2-b]furazanopyrazines through combination of the SNH and Heck reactions.” Mendeleev Communications, vol. 33, no. 6, Nov. 2023, pp. 753-755. https://doi.org/10.1016/j.mencom.2023.10.004.