Non-covalent conjugate based on graphene oxide and a cytotoxic agent containing 1,3,5-triazine derivative and (5-phenyl-2H-tetrazol-2-yl)acetoxy moiety: Synthesis, characterization, properties and cytotoxic activity
Olga V Mikolaichuk
1, 2
,
Olga S Shemchuk
2, 3
,
A V Protas
1, 2
,
E A Popova
1, 2
,
Dmitrii N. Maistrenko
1
,
O E Molchanov
1
,
Vladimir V. Sharoyko
1, 2, 3
,
Konstantin A. Semenov
1, 2, 3
3
Publication type: Journal Article
Publication date: 2023-11-29
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
The synthesis, identification and evaluation of the biological activity of a new non-covalent conjugate based on graphene oxide and (5-{[4,6-di(aziridin-1-yl)-1,3,5-triazin-2-yl]-amino}-2,2-dimethyl-1,3-dioxan-5-yl)methyl (5-phenyl-2H-tetrazol-2-yl)acetate were carried out. It was shown that the synthesized nanoconjugate is hemocompatible over the entire studied concentration range (10–100 μm) and demonstrates antiradical activity under irradiation. In addition, the conjugate exhibits cytotoxicity against A549 and HeLa cell lines with IC50 values of 4.0 and 73.7 μm, respectively.
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Mikolaichuk O. V. et al. Non-covalent conjugate based on graphene oxide and a cytotoxic agent containing 1,3,5-triazine derivative and (5-phenyl-2H-tetrazol-2-yl)acetoxy moiety: Synthesis, characterization, properties and cytotoxic activity // Mendeleev Communications. 2023. Vol. 33. No. 6. pp. 790-792.
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Mikolaichuk O. V., Shemchuk O. S., Protas A. V., Popova E. A., Ostrovskii V. A., Maistrenko D. N., Molchanov O. E., Sharoyko V., Semenov K. A. Non-covalent conjugate based on graphene oxide and a cytotoxic agent containing 1,3,5-triazine derivative and (5-phenyl-2H-tetrazol-2-yl)acetoxy moiety: Synthesis, characterization, properties and cytotoxic activity // Mendeleev Communications. 2023. Vol. 33. No. 6. pp. 790-792.
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TY - JOUR
DO - 10.1016/j.mencom.2023.10.017
UR - https://doi.org/10.1016/j.mencom.2023.10.017
TI - Non-covalent conjugate based on graphene oxide and a cytotoxic agent containing 1,3,5-triazine derivative and (5-phenyl-2H-tetrazol-2-yl)acetoxy moiety: Synthesis, characterization, properties and cytotoxic activity
T2 - Mendeleev Communications
AU - Mikolaichuk, Olga V
AU - Shemchuk, Olga S
AU - Protas, A V
AU - Popova, E A
AU - Ostrovskii, Vladimir A.
AU - Maistrenko, Dmitrii N.
AU - Molchanov, O E
AU - Sharoyko, Vladimir V.
AU - Semenov, Konstantin A.
PY - 2023
DA - 2023/11/29
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 790-792
IS - 6
VL - 33
SN - 0959-9436
SN - 1364-551X
ER -
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BibTex (up to 50 authors)
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@article{2023_Mikolaichuk,
author = {Olga V Mikolaichuk and Olga S Shemchuk and A V Protas and E A Popova and Vladimir A. Ostrovskii and Dmitrii N. Maistrenko and O E Molchanov and Vladimir V. Sharoyko and Konstantin A. Semenov},
title = {Non-covalent conjugate based on graphene oxide and a cytotoxic agent containing 1,3,5-triazine derivative and (5-phenyl-2H-tetrazol-2-yl)acetoxy moiety: Synthesis, characterization, properties and cytotoxic activity},
journal = {Mendeleev Communications},
year = {2023},
volume = {33},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {nov},
url = {https://doi.org/10.1016/j.mencom.2023.10.017},
number = {6},
pages = {790--792},
doi = {10.1016/j.mencom.2023.10.017}
}
Cite this
MLA
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Mikolaichuk, Olga V., et al. “Non-covalent conjugate based on graphene oxide and a cytotoxic agent containing 1,3,5-triazine derivative and (5-phenyl-2H-tetrazol-2-yl)acetoxy moiety: Synthesis, characterization, properties and cytotoxic activity.” Mendeleev Communications, vol. 33, no. 6, Nov. 2023, pp. 790-792. https://doi.org/10.1016/j.mencom.2023.10.017.