Myrtenyl-bispidine containing azole: synthesis and antifungal activity
N S Li Zhulanov
1
,
Suat Sari
2
,
Dolunay Gulmez
3
,
Sevtap Arikan-Akdagli
3
,
V I Krasnov
1
,
E.V. Suslov
1
,
Publication type: Journal Article
Publication date: 2024-01-01
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
A new monoterpene–azole hybrid containing myrtenyl- bispidine moiety, 2-(2,4-difluorophenyl)-1-(7-{[(1R,5S)-6,6- dimethylbicyclo[3.1.1]hept-2-en-2-yl]methyl}-1,5-dimethyl- 3,7-diazabicyclo[3.3.1]non-3-yl)-3-(1H-1,2,4-triazol-1-yl)- propan-2-ol was prepared in six steps with 55% overall yield. The compound was tested against a number of Candida spp. fungi and found to be active against Candida albicans. Molecular docking suggested possible inhibition of lanosterol 14α-demethylase (CYP51), a membrane enzyme targeted by azole antifungals.
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Total citations:
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Citations from 2025:
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(33.33%)
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Li Zhulanov N. S. et al. Myrtenyl-bispidine containing azole: synthesis and antifungal activity // Mendeleev Communications. 2024. Vol. 34. No. 1. pp. 119-121.
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Li Zhulanov N. S., Ponomarev K., Sari S., Gulmez D., Arikan-Akdagli S., Krasnov V. I., Suslov E., Volcho K. P., Salakhutdinov N. F. Myrtenyl-bispidine containing azole: synthesis and antifungal activity // Mendeleev Communications. 2024. Vol. 34. No. 1. pp. 119-121.
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RIS
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TY - JOUR
DO - 10.1016/j.mencom.2024.01.036
UR - https://doi.org/10.1016/j.mencom.2024.01.036
TI - Myrtenyl-bispidine containing azole: synthesis and antifungal activity
T2 - Mendeleev Communications
AU - Li Zhulanov, N S
AU - Ponomarev, Konstantin
AU - Sari, Suat
AU - Gulmez, Dolunay
AU - Arikan-Akdagli, Sevtap
AU - Krasnov, V I
AU - Suslov, E.V.
AU - Volcho, Konstantin P.
AU - Salakhutdinov, Nariman F.
PY - 2024
DA - 2024/01/01
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 119-121
IS - 1
VL - 34
SN - 0959-9436
SN - 1364-551X
ER -
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@article{2024_Li Zhulanov,
author = {N S Li Zhulanov and Konstantin Ponomarev and Suat Sari and Dolunay Gulmez and Sevtap Arikan-Akdagli and V I Krasnov and E.V. Suslov and Konstantin P. Volcho and Nariman F. Salakhutdinov},
title = {Myrtenyl-bispidine containing azole: synthesis and antifungal activity},
journal = {Mendeleev Communications},
year = {2024},
volume = {34},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {jan},
url = {https://doi.org/10.1016/j.mencom.2024.01.036},
number = {1},
pages = {119--121},
doi = {10.1016/j.mencom.2024.01.036}
}
Cite this
MLA
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Li Zhulanov, N. S., et al. “Myrtenyl-bispidine containing azole: synthesis and antifungal activity.” Mendeleev Communications, vol. 34, no. 1, Jan. 2024, pp. 119-121. https://doi.org/10.1016/j.mencom.2024.01.036.