Cajaninstilbene acid analogues as novel quorum sensing and biofilm inhibitors of Pseudomonas aeruginosa
Publication type: Journal Article
Publication date: 2020-11-01
scimago Q2
wos Q2
SJR: 0.825
CiteScore: 6.7
Impact factor: 3.5
ISSN: 08824010, 10961208
PubMed ID:
32771657
Microbiology
Infectious Diseases
Abstract
Biofilm formation and virulence factor secretion in opportunistic pathogen Pseudomonas aeruginosa are essential for establishment of chronic and recurrent infection, which are regulated by quorum sensing (QS) system. In this study, a set of cajaninstilbene acid analogues were designed and synthesized, and their abilities to inhibit QS and biofilm formation were investigated. Among all the compounds, compounds 3g, 3m and 3o showed potent anti-biofilm activity, especially 3o exhibited promising biofilm inhibitory activity with biofilm inhibition ratio of 49.50 ± 1.35% at 50 μM. Three lacZ reporter strains were constructed to identify the effects of compound 3o on different QS systems. Compound 3o showed the suppression on the expression of lasB-lacZ and pqsA-lacZ as well as on the production of their corresponding virulence factors. Therefore, compound 3o is expected to be generated as a lead compound with inhibition of biofilm formation and QS of Pseudomonas aeruginosa.
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15
Total citations:
15
Citations from 2025:
6
(42.85%)
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GOST
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Huang Z. X. et al. Cajaninstilbene acid analogues as novel quorum sensing and biofilm inhibitors of Pseudomonas aeruginosa // Microbial Pathogenesis. 2020. Vol. 148. p. 104414.
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Huang Z. X., Yu J., Xu X., Xu X., Zeng T., Lin J., Chen W. Cajaninstilbene acid analogues as novel quorum sensing and biofilm inhibitors of Pseudomonas aeruginosa // Microbial Pathogenesis. 2020. Vol. 148. p. 104414.
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RIS
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TY - JOUR
DO - 10.1016/j.micpath.2020.104414
UR - https://doi.org/10.1016/j.micpath.2020.104414
TI - Cajaninstilbene acid analogues as novel quorum sensing and biofilm inhibitors of Pseudomonas aeruginosa
T2 - Microbial Pathogenesis
AU - Huang, Zhi Xing
AU - Yu, Jia-Hui
AU - Xu, Xing-Jun
AU - Xu, Xiaofang
AU - Zeng, Ting
AU - Lin, Jing
AU - Chen, Weimin
PY - 2020
DA - 2020/11/01
PB - Elsevier
SP - 104414
VL - 148
PMID - 32771657
SN - 0882-4010
SN - 1096-1208
ER -
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BibTex (up to 50 authors)
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@article{2020_Huang,
author = {Zhi Xing Huang and Jia-Hui Yu and Xing-Jun Xu and Xiaofang Xu and Ting Zeng and Jing Lin and Weimin Chen},
title = {Cajaninstilbene acid analogues as novel quorum sensing and biofilm inhibitors of Pseudomonas aeruginosa},
journal = {Microbial Pathogenesis},
year = {2020},
volume = {148},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.micpath.2020.104414},
pages = {104414},
doi = {10.1016/j.micpath.2020.104414}
}