Microchemical Journal, volume 183, pages 107991
Development of heterocyclic 2,7-diamino-3-phenylazo-6-phenylpyrazolo[1,5-a]pyrimidine as antimicrobial agent and selective probe for UV–visible and colorimetric detection of Hg2+ ions
Aggarwal R.
1, 2
,
Kumar Suresh
2, 3
,
Virender
2
,
Kumar Ashwani
2
,
Mohan Brij
4
,
Sharma Deepansh
5
,
Kumar Vanish
6
1
CSIR-National Institute of Science, Communication and Policy Research, Dr. KS Krishnan Marg, PUSA Campus, New Delhi 110012, India
|
3
Department of Chemistry, Shaheed Udham Singh, Govt. College, Matak Majri, Karnal, India
|
Publication type: Journal Article
Publication date: 2022-12-01
Journal:
Microchemical Journal
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 4.8
ISSN: 0026265X
Spectroscopy
Analytical Chemistry
Abstract
• The synthesis of heterocyclic 2,7-diamino-3-phenylazo-6-phenylpyrazolo[1,5- a ]pyrimidine (PPD) was carried out under multicomponent conditions. • PPD was found to be selective chemosensor for Hg 2+ ions in metal sensing experiments with low detection limit. • PPD also displayed colourimetric signal on binding with Hg 2+ ions by changing the solution from colourless to yellow. • The synthesized derivative PPD was evaluated for its antimicrobial potential against seven bacterial strains and one fungal strain and it displayed excellent antibacterial activity equivalent to standard drug amoxicillin. • It was found non-toxic to normal cells in cytotoxicity experiments. Mercury is considered as a highly toxic metal ion due to its lethal effects on humans and the ecological system. The increasing level of antimicrobial resistance are threatening to the ecosystem, public health and economy. Development of new environmentally safe organic molecules can be a potential cure for both of the above-mentioned problems. Herein, we have synthesized 2,7-diamino-3-phenylazo-6-phenylpyrazolo[1,5- a ]pyrimidine ( PPD ) as a new hetero-cyclic ligand, act as a selective Hg 2+ ion chemosensor.The developed sensing probe PPD exhibitedlimit of detection (LOD) 1.31 × 10 -6 M, and limit of quantitation (LOQ) 4.39 × 10 -6 M in the linear range2.7-45.65 × 10 -6 M with good association affinity of 1.668x 10 4 M -1 for Hg 2+ ions.Interestingly, the synthesized heterocyclic motif (PPD) provided a significant colorimetric change from colorless to yellowupon binding with Hg 2+ ions.Moreover, the developed probe exhibited tremendous antimicrobial activity against seven bacterial strains and one fungal strain. Cytotoxic studies towards normal cell lines were also carried out for this compound which proved that compound is non-toxic (91-100 % cell survival) and can be applied to living system for mercury poisoning detection.
Citations by journals
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1
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Critical Reviews in Analytical Chemistry
1 publication, 20%
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Citations by publishers
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1
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Elsevier
3 publications, 60%
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Taylor & Francis
1 publication, 20%
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Springer Nature
1 publication, 20%
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- We do not take into account publications that without a DOI.
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Aggarwal R. et al. Development of heterocyclic 2,7-diamino-3-phenylazo-6-phenylpyrazolo[1,5-a]pyrimidine as antimicrobial agent and selective probe for UV–visible and colorimetric detection of Hg2+ ions // Microchemical Journal. 2022. Vol. 183. p. 107991.
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Aggarwal R., Kumar S., Virender, Kumar A., Mohan B., Sharma D., Kumar V. Development of heterocyclic 2,7-diamino-3-phenylazo-6-phenylpyrazolo[1,5-a]pyrimidine as antimicrobial agent and selective probe for UV–visible and colorimetric detection of Hg2+ ions // Microchemical Journal. 2022. Vol. 183. p. 107991.
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TY - JOUR
DO - 10.1016/j.microc.2022.107991
UR - https://doi.org/10.1016/j.microc.2022.107991
TI - Development of heterocyclic 2,7-diamino-3-phenylazo-6-phenylpyrazolo[1,5-a]pyrimidine as antimicrobial agent and selective probe for UV–visible and colorimetric detection of Hg2+ ions
T2 - Microchemical Journal
AU - Aggarwal, R.
AU - Kumar, Suresh
AU - Virender
AU - Kumar, Ashwani
AU - Mohan, Brij
AU - Sharma, Deepansh
AU - Kumar, Vanish
PY - 2022
DA - 2022/12/01 00:00:00
PB - Elsevier
SP - 107991
VL - 183
SN - 0026-265X
ER -
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@article{2022_Aggarwal,
author = {R. Aggarwal and Suresh Kumar and Virender and Ashwani Kumar and Brij Mohan and Deepansh Sharma and Vanish Kumar},
title = {Development of heterocyclic 2,7-diamino-3-phenylazo-6-phenylpyrazolo[1,5-a]pyrimidine as antimicrobial agent and selective probe for UV–visible and colorimetric detection of Hg2+ ions},
journal = {Microchemical Journal},
year = {2022},
volume = {183},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.microc.2022.107991},
pages = {107991},
doi = {10.1016/j.microc.2022.107991}
}