Open Access

Molecular Cell, volume 56, issue 1, pages 128-139

Integrator Regulates Transcriptional Initiation and Pause Release following Activation

Gardini Alessandro ^{1, 2}

Baillat David ³

Cesaroni Matteo ⁴

Hu Deqing ⁵

Marinis Jill M ⁶

Wagner Eric J ³

Lazar M. A. ⁷

Shilatifard Ali ⁵

Shiekhattar Ramin ^{1, 2}

Hide authors affiliations Show authors affiliations: 7 affiliations

University Of Miami |

Wistar Institute

University of Texas Health Science Center at Houston |

⁴

The Fels Institute, Temple University School of Medicine, Philadelphia, PA 19140, USA. |

⁵

Stowers Institute for Medical Research, Kansas City, MO, 64110, USA, |

⁶

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. |

⁷

* University of Pennsylvania. |

Publication type: Journal Article

Publication date: 2014-10-01

Elsevier

Journal: Molecular Cell

Quartile SCImago

Quartile WOS

Impact factor: 16

ISSN: 10972765, 10974164

DOI: 10.1016/j.molcel.2014.08.004

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PubMed ID: 25201415

Molecular Biology

Cell Biology

Abstract

In unicellular organisms, initiation is the rate-limiting step in transcription; in metazoan organisms, the transition from initiation to productive elongation is also important. Here, we show that the RNA polymerase II (RNAPII)-associated multiprotein complex, Integrator, plays a critical role in both initiation and the release of paused RNAPII at immediate early genes (IEGs) following transcriptional activation by epidermal growth factor (EGF) in human cells. Integrator is recruited to the IEGs in a signal-dependent manner and is required to engage and recruit the super elongation complex (SEC) to EGF-responsive genes to allow release of paused RNAPII and productive transcription elongation.

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Journal of Biological Chemistry	Journal of Biological Chemistry, 2, 1.43% Journal of Biological Chemistry 2 publications, 1.43%
Transcription	Transcription, 2, 1.43% Transcription 2 publications, 1.43%
EMBO Reports	EMBO Reports, 2, 1.43% EMBO Reports 2 publications, 1.43%
Genes	Genes, 1, 0.71% Genes 1 publication, 0.71%
Journal of Immunology	Journal of Immunology, 1, 0.71% Journal of Immunology 1 publication, 0.71%
Biochemistry and Cell Biology	Biochemistry and Cell Biology, 1, 0.71% Biochemistry and Cell Biology 1 publication, 0.71%
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	5 10 15 20 25 30 35 40
Elsevier	Elsevier, 38, 27.14% Elsevier 38 publications, 27.14%
Springer Nature	Springer Nature, 24, 17.14% Springer Nature 24 publications, 17.14%
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EMBO press	EMBO press, 3, 2.14% EMBO press 3 publications, 2.14%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 3, 2.14% Proceedings of the National Academy of Sciences (PNAS) 3 publications, 2.14%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 2, 1.43% Multidisciplinary Digital Publishing Institute (MDPI) 2 publications, 1.43%
The Royal Society	The Royal Society, 2, 1.43% The Royal Society 2 publications, 1.43%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 2, 1.43% American Society for Biochemistry and Molecular Biology 2 publications, 1.43%
Wiley	Wiley, 2, 1.43% Wiley 2 publications, 1.43%
Taylor & Francis	Taylor & Francis, 2, 1.43% Taylor & Francis 2 publications, 1.43%
The American Association of Immunologists	The American Association of Immunologists, 1, 0.71% The American Association of Immunologists 1 publication, 0.71%
Canadian Science Publishing	Canadian Science Publishing, 1, 0.71% Canadian Science Publishing 1 publication, 0.71%
Portland Press	Portland Press, 1, 0.71% Portland Press 1 publication, 0.71%
American Society for Microbiology	American Society for Microbiology, 1, 0.71% American Society for Microbiology 1 publication, 0.71%
American Society of Hematology	American Society of Hematology, 1, 0.71% American Society of Hematology 1 publication, 0.71%
Genetics Society of America	Genetics Society of America, 1, 0.71% Genetics Society of America 1 publication, 0.71%
	5 10 15 20 25 30 35 40

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Gardini A. et al. Integrator Regulates Transcriptional Initiation and Pause Release following Activation // Molecular Cell. 2014. Vol. 56. No. 1. pp. 128-139.

GOST all authors (up to 50) Copy

Gardini A., Baillat D., Cesaroni M., Hu D., Marinis J. M., Wagner E. J., Lazar M. A., Shilatifard A., Shiekhattar R. Integrator Regulates Transcriptional Initiation and Pause Release following Activation // Molecular Cell. 2014. Vol. 56. No. 1. pp. 128-139.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.molcel.2014.08.004

UR - https://doi.org/10.1016%2Fj.molcel.2014.08.004

TI - Integrator Regulates Transcriptional Initiation and Pause Release following Activation

T2 - Molecular Cell

AU - Gardini, Alessandro

AU - Baillat, David

AU - Cesaroni, Matteo

AU - Hu, Deqing

AU - Marinis, Jill M

AU - Wagner, Eric J

AU - Lazar, M. A.

AU - Shilatifard, Ali

AU - Shiekhattar, Ramin

PY - 2014

DA - 2014/10/01 00:00:00

PB - Elsevier

SP - 128-139

IS - 1

VL - 56

PMID - 25201415

SN - 1097-2765

SN - 1097-4164

ER -

BibTex |

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BibTex Copy

@article{2014_Gardini,

author = {Alessandro Gardini and David Baillat and Matteo Cesaroni and Deqing Hu and Jill M Marinis and Eric J Wagner and M. A. Lazar and Ali Shilatifard and Ramin Shiekhattar},

title = {Integrator Regulates Transcriptional Initiation and Pause Release following Activation},

journal = {Molecular Cell},

year = {2014},

volume = {56},

publisher = {Elsevier},

month = {oct},

url = {https://doi.org/10.1016%2Fj.molcel.2014.08.004},

number = {1},

pages = {128--139},

doi = {10.1016/j.molcel.2014.08.004}

}

MLA

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MLA Copy

Gardini, Alessandro, et al. “Integrator Regulates Transcriptional Initiation and Pause Release following Activation.” Molecular Cell, vol. 56, no. 1, Oct. 2014, pp. 128-139. https://doi.org/10.1016%2Fj.molcel.2014.08.004.

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Elsevier

Journal

Molecular Cell

Quartile SCImago

Quartile WOS

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10972765 (Print)
10974164 (Electronic)