HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity
Publication type: Journal Article
Publication date: 2016-05-01
scimago Q1
wos Q1
SJR: 9.051
CiteScore: 24.4
Impact factor: 16.6
ISSN: 10972765, 10974164
PubMed ID:
27067600
Molecular Biology
Cell Biology
Abstract
We report the identification of histone PARylation factor 1 (HPF1; also known as C4orf27) as a regulator of ADP-ribosylation signaling in the DNA damage response. HPF1/C4orf27 forms a robust protein complex with PARP-1 in cells and is recruited to DNA lesions in a PARP-1-dependent manner, but independently of PARP-1 catalytic ADP-ribosylation activity. Functionally, HPF1 promotes PARP-1-dependent in trans ADP-ribosylation of histones and limits DNA damage-induced hyper-automodification of PARP-1. Human cells lacking HPF1 exhibit sensitivity to DNA damaging agents and PARP inhibition, thereby suggesting an important role for HPF1 in genome maintenance and regulating the efficacy of PARP inhibitors. Collectively, our results demonstrate how a fundamental step in PARP-1-dependent ADP-ribosylation signaling is regulated and suggest that HPF1 functions at the crossroads of histone ADP-ribosylation and PARP-1 automodification.
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Metrics
285
Total citations:
285
Citations from 2024:
79
(27.72%)
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GOST
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Gibbs Seymour I. et al. HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity // Molecular Cell. 2016. Vol. 62. No. 3. pp. 432-442.
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Gibbs Seymour I., Fontana P., Rack J. G. M., Ahel I. HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity // Molecular Cell. 2016. Vol. 62. No. 3. pp. 432-442.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.molcel.2016.03.008
UR - https://doi.org/10.1016/j.molcel.2016.03.008
TI - HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity
T2 - Molecular Cell
AU - Gibbs Seymour, Ian
AU - Fontana, Pietro
AU - Rack, Johannes Gregor Matthias
AU - Ahel, Ivan
PY - 2016
DA - 2016/05/01
PB - Elsevier
SP - 432-442
IS - 3
VL - 62
PMID - 27067600
SN - 1097-2765
SN - 1097-4164
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Gibbs Seymour,
author = {Ian Gibbs Seymour and Pietro Fontana and Johannes Gregor Matthias Rack and Ivan Ahel},
title = {HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity},
journal = {Molecular Cell},
year = {2016},
volume = {62},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016/j.molcel.2016.03.008},
number = {3},
pages = {432--442},
doi = {10.1016/j.molcel.2016.03.008}
}
Cite this
MLA
Copy
Gibbs Seymour, Ian, et al. “HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity.” Molecular Cell, vol. 62, no. 3, May. 2016, pp. 432-442. https://doi.org/10.1016/j.molcel.2016.03.008.