Serine ADP-Ribosylation Depends on HPF1
Publication type: Journal Article
Publication date: 2017-03-01
scimago Q1
wos Q1
SJR: 9.051
CiteScore: 24.4
Impact factor: 16.6
ISSN: 10972765, 10974164
PubMed ID:
28190768
Molecular Biology
Cell Biology
Abstract
ADP-ribosylation (ADPr) regulates important patho-physiological processes through its attachment to different amino acids in proteins. Recently, by precision mapping on all possible amino acid residues, we identified histone serine ADPr marks in the DNA damage response. However, the biochemical basis underlying this serine modification remained unknown. Here we report that serine ADPr is strictly dependent on histone PARylation factor 1 (HPF1), a recently identified regulator of PARP-1. Quantitative proteomics revealed that serine ADPr does not occur in cells lacking HPF1. Moreover, adding HPF1 to in vitro PARP-1/PARP-2 reactions is necessary and sufficient for serine-specific ADPr of histones and PARP-1 itself. Three endogenous serine ADPr sites are located on the PARP-1 automodification domain. Further identification of serine ADPr on HMG proteins and hundreds of other targets indicates that serine ADPr is a widespread modification. We propose that O-linked protein ADPr is the key signal in PARP-1/PARP-2-dependent processes that govern genome stability.
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Metrics
325
Total citations:
325
Citations from 2024:
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(26.77%)
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GOST
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Bonfiglio J. J. et al. Serine ADP-Ribosylation Depends on HPF1 // Molecular Cell. 2017. Vol. 65. No. 5. pp. 932-940000000.
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Bonfiglio J. J., Fontana P., Zhang Q., Colby T., Gibbs Seymour I., Atanassov I., Bartlett E. E., Žaja R., Ahel I., Matić I. Serine ADP-Ribosylation Depends on HPF1 // Molecular Cell. 2017. Vol. 65. No. 5. pp. 932-940000000.
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RIS
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TY - JOUR
DO - 10.1016/j.molcel.2017.01.003
UR - https://doi.org/10.1016/j.molcel.2017.01.003
TI - Serine ADP-Ribosylation Depends on HPF1
T2 - Molecular Cell
AU - Bonfiglio, Juan José
AU - Fontana, Pietro
AU - Zhang, Qi
AU - Colby, Thomas
AU - Gibbs Seymour, Ian
AU - Atanassov, Ilian
AU - Bartlett, Edward E.
AU - Žaja, Roko
AU - Ahel, Ivan
AU - Matić, Ivan
PY - 2017
DA - 2017/03/01
PB - Elsevier
SP - 932-940000000
IS - 5
VL - 65
PMID - 28190768
SN - 1097-2765
SN - 1097-4164
ER -
Cite this
BibTex (up to 50 authors)
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@article{2017_Bonfiglio,
author = {Juan José Bonfiglio and Pietro Fontana and Qi Zhang and Thomas Colby and Ian Gibbs Seymour and Ilian Atanassov and Edward E. Bartlett and Roko Žaja and Ivan Ahel and Ivan Matić},
title = {Serine ADP-Ribosylation Depends on HPF1},
journal = {Molecular Cell},
year = {2017},
volume = {65},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/j.molcel.2017.01.003},
number = {5},
pages = {932--940000000},
doi = {10.1016/j.molcel.2017.01.003}
}
Cite this
MLA
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Bonfiglio, Juan José, et al. “Serine ADP-Ribosylation Depends on HPF1.” Molecular Cell, vol. 65, no. 5, Mar. 2017, pp. 932-940000000. https://doi.org/10.1016/j.molcel.2017.01.003.