Open Access
Journal of Molecular Liquids, volume 336, pages 116874
Carboxymethyl chitosan/ionic liquid imidazolium-based nanoparticles as nanocarriers for zinc phthalocyanine and its photodynamic activity
Patrícia Regina Ebani
1
,
Luiza Stefanello
1
,
Bruna L Kuhn
1
,
Clarissa P. Frizzo
1
,
Thiago A. L. Burgo
2
,
Carmen Luisa Kloster
2
,
Marcos Antonio Villetti
2
1
Department of Chemistry, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil.
|
2
Department of Physics, Universidade Federal de Santa Maria - UFSM , Santa Maria, RS, Brazil
|
Publication type: Journal Article
Publication date: 2021-08-01
Journal:
Journal of Molecular Liquids
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 6
ISSN: 01677322, 18733166
Materials Chemistry
Electronic, Optical and Magnetic Materials
Physical and Theoretical Chemistry
Spectroscopy
Atomic and Molecular Physics, and Optics
Condensed Matter Physics
Abstract
• New third-generation photosensitizers were developed for use in photodynamic therapy. • CMC/IL based nanoparticles loaded with ZnPc showed high photodynamic activity. • The production of singlet oxygen depends on the nature of polymer and stabilizer. New nanocarriers have contributed to develop the so-called third-generation photosensitizers for use in the photodynamic therapy (PDT). In this paper, nanoparticles based on carboxymethyl chitosan (CMC) and a monocationic ionic liquid imidazolium-based (IL) (1-dodecyl-3-methylimidazolium bromide, C 12 MIMBr), loaded with photosensitizer zinc phthalocyanine (ZnPc) was developed for application in PDT. The CMC/IL@ZnPc nanoparticles were characterized by their physicochemical properties, photodynamic activity and drug release profile, and while their performances were compared with those containing conventional surfactants. The polymeric nanoparticles display a nanometric hydrodynamic radius, low polydispersity index, negative zeta potential, high drug loading and encapsulation efficiencies higher than 98%. Moreover, CMC/IL@ZnPc nanoparticles have the ability to produce cytotoxic singlet oxygen ( 1 O 2 ) and the values of singlet oxygen quantum yields (Φ Δ ) are appropriated for application in PDT. In vitro release kinetic of ZnPc from nanoparticles exhibited a sustained release profile controlled by diffusion, without burst effect. Our findings highlight that CMC/IL-based nanoparticles have potential to be employed as nanocarriers for hydrophobic photosensitizers in PDT.
Top-30
Citations by journals
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Journal of Molecular Liquids
3 publications, 18.75%
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Pharmaceutics
2 publications, 12.5%
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Polymers
1 publication, 6.25%
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Molecules
1 publication, 6.25%
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Current Opinion in Colloid and Interface Science
1 publication, 6.25%
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RSC Advances
1 publication, 6.25%
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Chemical Society Reviews
1 publication, 6.25%
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Journal of Biomaterials Science, Polymer Edition
1 publication, 6.25%
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Reactive and Functional Polymers
1 publication, 6.25%
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Journal of Drug Delivery Science and Technology
1 publication, 6.25%
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Russian Chemical Reviews
1 publication, 6.25%
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Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
1 publication, 6.25%
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Analytica Chimica Acta
1 publication, 6.25%
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Citations by publishers
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8
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Elsevier
8 publications, 50%
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Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 25%
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Royal Society of Chemistry (RSC)
2 publications, 12.5%
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Taylor & Francis
1 publication, 6.25%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 6.25%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Regina Ebani P. et al. Carboxymethyl chitosan/ionic liquid imidazolium-based nanoparticles as nanocarriers for zinc phthalocyanine and its photodynamic activity // Journal of Molecular Liquids. 2021. Vol. 336. p. 116874.
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Regina Ebani P., Stefanello L., Kuhn B. L., Frizzo C. P., Burgo T. A. L., Luisa Kloster C., Villetti M. A. Carboxymethyl chitosan/ionic liquid imidazolium-based nanoparticles as nanocarriers for zinc phthalocyanine and its photodynamic activity // Journal of Molecular Liquids. 2021. Vol. 336. p. 116874.
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TY - JOUR
DO - 10.1016/j.molliq.2021.116874
UR - https://doi.org/10.1016/j.molliq.2021.116874
TI - Carboxymethyl chitosan/ionic liquid imidazolium-based nanoparticles as nanocarriers for zinc phthalocyanine and its photodynamic activity
T2 - Journal of Molecular Liquids
AU - Regina Ebani, Patrícia
AU - Stefanello, Luiza
AU - Kuhn, Bruna L
AU - Frizzo, Clarissa P.
AU - Burgo, Thiago A. L.
AU - Luisa Kloster, Carmen
AU - Villetti, Marcos Antonio
PY - 2021
DA - 2021/08/01 00:00:00
PB - Elsevier
SP - 116874
VL - 336
SN - 0167-7322
SN - 1873-3166
ER -
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@article{2021_Regina Ebani,
author = {Patrícia Regina Ebani and Luiza Stefanello and Bruna L Kuhn and Clarissa P. Frizzo and Thiago A. L. Burgo and Carmen Luisa Kloster and Marcos Antonio Villetti},
title = {Carboxymethyl chitosan/ionic liquid imidazolium-based nanoparticles as nanocarriers for zinc phthalocyanine and its photodynamic activity},
journal = {Journal of Molecular Liquids},
year = {2021},
volume = {336},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.molliq.2021.116874},
pages = {116874},
doi = {10.1016/j.molliq.2021.116874}
}