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Journal of Molecular Liquids, volume 368, pages 120807

Encapsulation of the quercetin with interpolyelectrolyte complex based on pillar[5]arenes

Nazarova Anastasia ¹

Yakimova Luidmila ¹

Mostovaya O A ¹

Kulikova T. V. ¹

Mikhailovа Olga ¹

Evtugyn Gennady ¹

Ganeeva Irina ²

Bulatov Emil R. ²

Stoikov Ivan ^{1, 3}

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A.M. Butlerov Chemistry Institute of Kazan Federal University, 18 Kremlyovskaya Str., 420008 Kazan, Russia |

Institute of Fundamental Medicine and Biology of Kazan Federal University, 18 Kremlyovskaya Str., 420008 Kazan, Russia |

Federal Center for Toxicological, Radiation and Biological Safety, 2 Nauchny Gorodok Str., Kazan 420075, Russia |

Publication type: Journal Article

Publication date: 2022-12-01

Elsevier

Journal: Journal of Molecular Liquids

Quartile SCImago

Quartile WOS

Impact factor: 6

ISSN: 01677322, 18733166

DOI: 10.1016/j.molliq.2022.120807

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Materials Chemistry

Electronic, Optical and Magnetic Materials

Physical and Theoretical Chemistry

Spectroscopy

Atomic and Molecular Physics, and Optics

Condensed Matter Physics

Abstract

• New interpolyelectrolyte non-toxic complexes based on the self-assembly of water-soluble pillar [5] arenes were obtained. • Spherical aggregates with an average diameter of 10 nm are found. • Interpolyelectrolyte complex more efficiently binds quercetin (pK a 5.13) compared with individual macrocycles. • The influence of the pH media on the ability of quercetin to be released from the IPEC was shown. The using of pH-sensitive delivery systems is a promising strategy to significantly improve the pharmacological properties of water-insoluble drugs. Herein, we propose and develop an approach to synthesis of interpolyelectrolyte complexes based on combination of two water-soluble decasubstituted non-toxic pillar [5] arenes for encapsulation poor-soluble quercetin and its subsequent release depending on the pH. Interpolyelectrolytes were obtained by mixing aqueous solutions one of which contained a polycationic (ammonium) and the other - a polyanionic (carboxylate) components. The shape and size evolution of interpolyelectrolytes were studied by dynamic light scattering and transmission electron microscopy. Spherical aggregates with an average diameter of 10 nm are found. The ability to form complexes and associates with quercetin by polycationic and polyanionic macrocycle, as well as an interpolyelectrolyte complex based on them, was studied by electron UV-vis and fluorescence spectroscopy, dynamic light scattering. Interpolyelectrolyte complex more efficiently binds quercetin (pK a 5.13) compared with individual macrocycles due to the greater stability of the associates formed by IPEC. The release of quercetin from the interpolyelectrolyte complex was studied in acidic (pH=4.00), weakly acidic (pH=5.00-5.5), neutral (pH=7.44) and weakly alkaline (pH=8.15) solutions. It was found the full release of the quercetin without oxidation of flavonoid is observed in the neutral solution. This work provides important guidance for the design of successful delivery systems via optimizing the structure and composition of nanocapsules.

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Citations by journals

	1
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 20% International Journal of Molecular Sciences 1 publication, 20%
Pharmaceutics	Pharmaceutics, 1, 20% Pharmaceutics 1 publication, 20%
Bioorganic Chemistry	Bioorganic Chemistry, 1, 20% Bioorganic Chemistry 1 publication, 20%
Polymers	Polymers, 1, 20% Polymers 1 publication, 20%
Journal of Materials Chemistry B	Journal of Materials Chemistry B, 1, 20% Journal of Materials Chemistry B 1 publication, 20%
	1

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	1 2 3
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 3, 60% Multidisciplinary Digital Publishing Institute (MDPI) 3 publications, 60%
Elsevier	Elsevier, 1, 20% Elsevier 1 publication, 20%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 20% Royal Society of Chemistry (RSC) 1 publication, 20%
	1 2 3

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Nazarova A. et al. Encapsulation of the quercetin with interpolyelectrolyte complex based on pillar[5]arenes // Journal of Molecular Liquids. 2022. Vol. 368. p. 120807.

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Nazarova A., Yakimova L., Mostovaya O. A., Kulikova T. V., Mikhailovа O., Evtugyn G., Ganeeva I., Bulatov E. R., Stoikov I. Encapsulation of the quercetin with interpolyelectrolyte complex based on pillar[5]arenes // Journal of Molecular Liquids. 2022. Vol. 368. p. 120807.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.molliq.2022.120807

UR - https://doi.org/10.1016%2Fj.molliq.2022.120807

TI - Encapsulation of the quercetin with interpolyelectrolyte complex based on pillar[5]arenes

T2 - Journal of Molecular Liquids

AU - Nazarova, Anastasia

AU - Yakimova, Luidmila

AU - Mostovaya, O A

AU - Kulikova, T. V.

AU - Mikhailovа, Olga

AU - Evtugyn, Gennady

AU - Ganeeva, Irina

AU - Bulatov, Emil R.

AU - Stoikov, Ivan

PY - 2022

DA - 2022/12/01 00:00:00

PB - Elsevier

SP - 120807

VL - 368

SN - 0167-7322

SN - 1873-3166

ER -

BibTex

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BibTex Copy

@article{2022_Nazarova,

author = {Anastasia Nazarova and Luidmila Yakimova and O A Mostovaya and T. V. Kulikova and Olga Mikhailovа and Gennady Evtugyn and Irina Ganeeva and Emil R. Bulatov and Ivan Stoikov},

title = {Encapsulation of the quercetin with interpolyelectrolyte complex based on pillar[5]arenes},

journal = {Journal of Molecular Liquids},

year = {2022},

volume = {368},

publisher = {Elsevier},

month = {dec},

url = {https://doi.org/10.1016%2Fj.molliq.2022.120807},

pages = {120807},

doi = {10.1016/j.molliq.2022.120807}

}

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Publisher

Elsevier

Journal

Journal of Molecular Liquids

Quartile SCImago

Quartile WOS

Impact factor

ISSN

01677322 (Print)
18733166 (Electronic)

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