Trends in Molecular Medicine, volume 26, issue 9, pages 848-861

G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies

Josué Carvalho ¹

Jean-Louis Mergny ^{2, 3}

Gilmar F. Salgado ²

João A Queiroz ¹

Luis Filipe Vieira Ferreira ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

CICS-UBI, Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal. |

University of Bordeaux, ARNA Laboratory, INSERM, U1212, CNRS UMR 5320, IECB, F-33600 Pessac, France |

Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, Brno, 612 65, Czech Republic. |

Publication type: Journal Article

Publication date: 2020-09-01

Elsevier

Journal: Trends in Molecular Medicine

Quartile SCImago

Quartile WOS

Impact factor: 13.6

ISSN: 14714914, 1471499X

DOI: 10.1016/j.molmed.2020.05.002

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Molecular Biology

Molecular Medicine

Abstract

The clinical applicability of G-quadruplexes (G4s) as anticancer drugs is currently being evaluated. Several G4 ligands and aptamers are undergoing clinical trials following the notable examples of quarfloxin and AS1411, respectively. In this review, we summarize the latest achievements and breakthroughs in the use of G4 nucleic acids as both therapeutic tools (‘friends', as healing anticancer drugs) and targets (‘foes', within the harmful cancer cell), particularly using aptamers and quadruplex-targeted ligands, respectively. We explore the recent research on synthetic G4 ligands toward the discovery of anticancer therapeutics and their mechanism of action. Additionally, we highlight recent advances in chemical and structural biology that enable the design of specific G4 aptamers to be used as novel anticancer agents.

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Carvalho J. et al. G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies // Trends in Molecular Medicine. 2020. Vol. 26. No. 9. pp. 848-861.

GOST all authors (up to 50) Copy

Carvalho J., Mergny J., Salgado G. F., Queiroz J. A., Ferreira L. F. V. G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies // Trends in Molecular Medicine. 2020. Vol. 26. No. 9. pp. 848-861.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.molmed.2020.05.002

UR - https://doi.org/10.1016/j.molmed.2020.05.002

TI - G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies

T2 - Trends in Molecular Medicine

AU - Carvalho, Josué

AU - Mergny, Jean-Louis

AU - Salgado, Gilmar F.

AU - Queiroz, João A

AU - Ferreira, Luis Filipe Vieira

PY - 2020

DA - 2020/09/01

PB - Elsevier

SP - 848-861

IS - 9

VL - 26

SN - 1471-4914

SN - 1471-499X

ER -

BibTex |

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BibTex Copy

@article{2020_Carvalho,

author = {Josué Carvalho and Jean-Louis Mergny and Gilmar F. Salgado and João A Queiroz and Luis Filipe Vieira Ferreira},

title = {G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies},

journal = {Trends in Molecular Medicine},

year = {2020},

volume = {26},

publisher = {Elsevier},

month = {sep},

url = {https://doi.org/10.1016/j.molmed.2020.05.002},

number = {9},

pages = {848--861},

doi = {10.1016/j.molmed.2020.05.002}

}

MLA

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MLA Copy

Carvalho, Josué, et al. “G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies.” Trends in Molecular Medicine, vol. 26, no. 9, Sep. 2020, pp. 848-861. https://doi.org/10.1016/j.molmed.2020.05.002.

Found error?

Publisher

Elsevier

Journal

Trends in Molecular Medicine

Quartile SCImago

Quartile WOS

Impact factor

13.6

ISSN

14714914 (Print)
1471499X (Electronic)