Mutation Research - Genetic Toxicology and Environmental Mutagenesis

, volume 805 , pages 46-57

Toxic and DNA damaging effects of a functionalized fullerene in human embryonic lung fibroblasts

Elizaveta Ershova ^{1, 2}

Vasilina Sergeeva ³

A I Chausheva ³

D G Zheglo ³

V A Nikitina ³

T D Smirnova ³

L V Kameneva ³

Lev N. Porokhovnik ³

Sergey Kutsev ^{1, 4}

Pavel A. Troshin ⁵

I I Voronov ⁵

E A Khakina ⁵

N N Veiko ^{1, 2}

Svetlana Kostyuk ³

Hide authors affiliations Show authors affiliations: 5 affiliations

Research Centre for Medical Genetics (RCMG), Moscow, 115478, Russia |

V. A. Negovsky Research Institute of General Reanimatology, Moscow, 107031, Russia. |

Research Centre for Medical Genetics (RCMG), Moscow, 115478, Russia. |

⁴

N.I. Pirogov Russian National Research Medical University, Moscow, 117997, Russia. |

⁵

Institute for Problems of Chemical Physics of Russian Academy of Sciences, Moscow Region, 142432, Russia |

Publication type: Journal Article

Publication date: 2016-07-01

Elsevier

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

scimago Q2

wos Q2

SJR: 0.668

CiteScore: 4.4

Impact factor: 2.5

ISSN: 13835718, 18793592

DOI: 10.1016/j.mrgentox.2016.05.004

Copy DOI

PubMed ID: 27402482

Genetics

Health, Toxicology and Mutagenesis

Abstract

Water-soluble fullerenes have been studied as potential nanovectors and therapeutic agents, but their possible toxicity is of concern. We have studied the effects of F-828, a soluble fullerene [C60] derivative, on diploid human embryonic lung fibroblasts (HELFs) in vitro. F-828 causes complex time-dependent changes in ROS levels. Inhibition of Nox4 activity by plumbagin blocks F-828-dependent ROS elevation. F-828 induces DNA breaks, as measured by the comet assay and γH2AX expression, and the activities of the transcription factors NF-kB and p53 increase. F-828 concentrations>25μM are cytotoxic; cell death occurs by necrosis. Expression levels of TGF-β, RHOA, RHOC, ROCK1, and SMAD2 increase following exposure to F-828. Our results raise the possibility that fullerene F-828 may induce pulmonary fibrosis in vivo.

Found

5 citations

Kraevaya Olga

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PhD in Chemistry

72 publications, 461 citations, 11 reviews

h-index: 12

Federal Research Center of Problem of Chemical Physics and Medicinal Chemistry RAS

2 citations

Mikheev Ivan

PhD in Chemistry

87 publications, 816 citations, 82 reviews

h-index: 17

Lomonosov Moscow State University

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GOST |

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GOST Copy

Ershova E. et al. Toxic and DNA damaging effects of a functionalized fullerene in human embryonic lung fibroblasts // Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 2016. Vol. 805. pp. 46-57.

GOST all authors (up to 50) Copy

Ershova E., Sergeeva V., Chausheva A. I., Zheglo D. G., Nikitina V. A., Smirnova T. D., Kameneva L. V., Porokhovnik L. N., Kutsev S., Troshin P. A., Voronov I. I., Khakina E. A., Veiko N. N., Kostyuk S. Toxic and DNA damaging effects of a functionalized fullerene in human embryonic lung fibroblasts // Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 2016. Vol. 805. pp. 46-57.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.mrgentox.2016.05.004

UR - https://doi.org/10.1016/j.mrgentox.2016.05.004

TI - Toxic and DNA damaging effects of a functionalized fullerene in human embryonic lung fibroblasts

T2 - Mutation Research - Genetic Toxicology and Environmental Mutagenesis

AU - Ershova, Elizaveta

AU - Sergeeva, Vasilina

AU - Chausheva, A I

AU - Zheglo, D G

AU - Nikitina, V A

AU - Smirnova, T D

AU - Kameneva, L V

AU - Porokhovnik, Lev N.

AU - Kutsev, Sergey

AU - Troshin, Pavel A.

AU - Voronov, I I

AU - Khakina, E A

AU - Veiko, N N

AU - Kostyuk, Svetlana

PY - 2016

DA - 2016/07/01

PB - Elsevier

SP - 46-57

VL - 805

PMID - 27402482

SN - 1383-5718

SN - 1879-3592

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2016_Ershova,

author = {Elizaveta Ershova and Vasilina Sergeeva and A I Chausheva and D G Zheglo and V A Nikitina and T D Smirnova and L V Kameneva and Lev N. Porokhovnik and Sergey Kutsev and Pavel A. Troshin and I I Voronov and E A Khakina and N N Veiko and Svetlana Kostyuk},

title = {Toxic and DNA damaging effects of a functionalized fullerene in human embryonic lung fibroblasts},

journal = {Mutation Research - Genetic Toxicology and Environmental Mutagenesis},

year = {2016},

volume = {805},

publisher = {Elsevier},

month = {jul},

url = {https://doi.org/10.1016/j.mrgentox.2016.05.004},

pages = {46--57},

doi = {10.1016/j.mrgentox.2016.05.004}

}

Publisher

Elsevier

Journal

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

scimago Q2

wos Q2

SJR

0.668

CiteScore

4.4

Impact factor

2.5

ISSN

13835718 (Print)

18793592 (Electronic)

Labs

Laboratory of Functional Materials for Electronics and Medicine

Profiles

Pavel A Troshin