Architecture-controlled release of ibuprofen from polymeric nanoparticles
Тип публикации: Journal Article
Дата публикации: 2020-12-01
scimago Q1
wos Q2
БС2
SJR: 0.788
CiteScore: 5.8
Impact factor: 4.5
ISSN: 23524928
Materials Chemistry
General Materials Science
Mechanics of Materials
Краткое описание
Smart polymeric systems are required that are able to release a therapeutic drug with control over timing and location of delivery. Herein we have investigated the architecture-controlled and pH-triggered release of ibuprofen from a polymeric nanoparticle system prepared using ring-opening metathesis polymerisation. The co-polymerisation of norbornene-derived ibuprofen (NB-Ibu) and poly(ethylene glycol) (NB-PEG) monomers produced polymers with block and random sequence architectures. Self-assembly into nanoparticle systems and release of ibuprofen only under basic conditions was shown to be controlled by polymer sequence.
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Shehata S., Serpell C. J., Biagini S. Architecture-controlled release of ibuprofen from polymeric nanoparticles // Materials Today Communications. 2020. Vol. 25. p. 101562.
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Shehata S., Serpell C. J., Biagini S. Architecture-controlled release of ibuprofen from polymeric nanoparticles // Materials Today Communications. 2020. Vol. 25. p. 101562.
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TY - JOUR
DO - 10.1016/j.mtcomm.2020.101562
UR - https://doi.org/10.1016/j.mtcomm.2020.101562
TI - Architecture-controlled release of ibuprofen from polymeric nanoparticles
T2 - Materials Today Communications
AU - Shehata, Sara
AU - Serpell, Christopher J
AU - Biagini, S.
PY - 2020
DA - 2020/12/01
PB - Elsevier
SP - 101562
VL - 25
SN - 2352-4928
ER -
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@article{2020_Shehata,
author = {Sara Shehata and Christopher J Serpell and S. Biagini},
title = {Architecture-controlled release of ibuprofen from polymeric nanoparticles},
journal = {Materials Today Communications},
year = {2020},
volume = {25},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.mtcomm.2020.101562},
pages = {101562},
doi = {10.1016/j.mtcomm.2020.101562}
}