Nanomedicine: Nanotechnology, Biology, and Medicine

, том 14 , издание 5 , страницы 1733-1742

Multimodal doxorubicin loaded magnetic nanoparticles for VEGF targeted theranostics of breast cancer.

Alevtina S. Semkina ^{1, 2}

Alexander S. Skorikov ³

Nadejda F Grinenko ⁴

Sergey A Cherepanov ^{1, 4}

Daniil A Vishnevskiy ¹

Klavdiya P Ionova ⁴

Maxim A. Abakumov ^{1, 5}

Tatiana O Abakumova ⁶

Pavel A Melnikov ⁴

Victor Naumenko ⁵

Alexander G. Majouga ^{5, 7, 8}

В. П. Чехонин ^{1, 4}

Скрыть аффилиации авторов Показать аффилиации авторов: 8 аффилиаций

Pirogov Russian National Research Medical University, Moscow, Russian Federation |

The National University of Science and Technology MISiS, Moscow, Russian Federation. |

Lomonosov Moscow State University , Moscow , Russian Federation |

⁴

Serbsky National Medical Research Center for Psychiatry and Narcology, Moscow, Russian Federation. |

⁵

The National University of Science and Technology MISiS, Moscow, Russian Federation |

⁶

Skolkovo Inst. of Science and Technology Moscow, Russian Federation |

⁷

Lomonosov Moscow State University, Moscow, Russian Federation |

⁸

Dmitry Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation. |

Тип публикации: Journal Article

Дата публикации: 2018-07-01

Elsevier

Nanomedicine: Nanotechnology, Biology, and Medicine

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wos Q2

БС1

SJR: 0.950

CiteScore: 10.4

Impact factor: 4.6

ISSN: 15499634, 15499642

DOI: 10.1016/j.nano.2018.04.019

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PubMed ID: 29730399

Medicine (miscellaneous)

Pharmaceutical Science

Molecular Medicine

General Materials Science

Bioengineering

Biomedical Engineering

Краткое описание

In presented paper we have developed new system for cancer theranostics based on vascular endothelial growth factor (VEGF) targeted magnetic nanoparticles. Conjugation of anti-VEGF antibodies with bovine serum albumin coated PEGylated magnetic nanoparticles allows for improved binding with murine breast adenocarcinoma 4T1 cell line and facilitates doxorubicin delivery to tumor cells. It was shown that intravenous injection of doxorubicin loaded VEGF targeted nanoparticles increases median survival rate of mice bearing 4T1 tumors up to 50%. On the other hand magnetic resonance imaging (MRI) of 4T1 tumors 24 h after intravenous injection showed accumulation of nanoparticles in tumors, thus allowing simultaneous cancer therapy and diagnostics.

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Национальный исследовательский технологический университет «МИСиС»

Российский национальный исследовательский медицинский университет имени Н. И. Пирогова

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Национальный исследовательский технологический университет «МИСиС»

Российский национальный исследовательский медицинский университет имени Н. И. Пирогова

Российский химико-технологический университет имени Д. И. Менделеева

Области научных интересов

Адресная доставка лекарств

Магнитная гипертермия

Магнитно-резонансная томография (МРТ)

Наночастицы оксидов металлов

Неорганическая химия

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Физический институт им. П.Н. Лебедева РАН

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Старчиков Сергей

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Semkina A. S. et al. Multimodal doxorubicin loaded magnetic nanoparticles for VEGF targeted theranostics of breast cancer. // Nanomedicine: Nanotechnology, Biology, and Medicine. 2018. Vol. 14. No. 5. pp. 1733-1742.

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Semkina A. S., Skorikov A. S., Grinenko N. F., Cherepanov S. A., Vishnevskiy D. A., Ionova K. P., Abakumov M. A., Abakumova T. O., Melnikov P. A., Naumenko V., Majouga A. G., Чехонин В. П. Multimodal doxorubicin loaded magnetic nanoparticles for VEGF targeted theranostics of breast cancer. // Nanomedicine: Nanotechnology, Biology, and Medicine. 2018. Vol. 14. No. 5. pp. 1733-1742.

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TY - JOUR

DO - 10.1016/j.nano.2018.04.019

UR - https://doi.org/10.1016/j.nano.2018.04.019

TI - Multimodal doxorubicin loaded magnetic nanoparticles for VEGF targeted theranostics of breast cancer.

T2 - Nanomedicine: Nanotechnology, Biology, and Medicine

AU - Semkina, Alevtina S.

AU - Skorikov, Alexander S.

AU - Grinenko, Nadejda F

AU - Cherepanov, Sergey A

AU - Vishnevskiy, Daniil A

AU - Ionova, Klavdiya P

AU - Abakumov, Maxim A.

AU - Abakumova, Tatiana O

AU - Melnikov, Pavel A

AU - Naumenko, Victor

AU - Majouga, Alexander G.

AU - Чехонин, В. П.

PY - 2018

DA - 2018/07/01

PB - Elsevier

SP - 1733-1742

IS - 5

VL - 14

PMID - 29730399

SN - 1549-9634

SN - 1549-9642

ER -

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@article{2018_Semkina,

author = {Alevtina S. Semkina and Alexander S. Skorikov and Nadejda F Grinenko and Sergey A Cherepanov and Daniil A Vishnevskiy and Klavdiya P Ionova and Maxim A. Abakumov and Tatiana O Abakumova and Pavel A Melnikov and Victor Naumenko and Alexander G. Majouga and В. П. Чехонин},

title = {Multimodal doxorubicin loaded magnetic nanoparticles for VEGF targeted theranostics of breast cancer.},

journal = {Nanomedicine: Nanotechnology, Biology, and Medicine},

year = {2018},

volume = {14},

publisher = {Elsevier},

month = {jul},

url = {https://doi.org/10.1016/j.nano.2018.04.019},

number = {5},

pages = {1733--1742},

doi = {10.1016/j.nano.2018.04.019}

}

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Semkina, Alevtina S., et al. “Multimodal doxorubicin loaded magnetic nanoparticles for VEGF targeted theranostics of breast cancer..” Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 14, no. 5, Jul. 2018, pp. 1733-1742. https://doi.org/10.1016/j.nano.2018.04.019.