NeuroToxicology, volume 91, pages 1-10
Prevention of anticancer therapy-induced neurotoxicity: Putting DNA damage in perspective
Publication type: Journal Article
Publication date: 2022-07-01
Journal:
NeuroToxicology
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 3.4
ISSN: 0161813X, 18729711
General Neuroscience
Toxicology
Abstract
Chemotherapy-induced peripheral neuropathy (CIPN) is a severe side effect of conventional anticancer therapeutics (cAT) that significantly impacts the quality of life of tumor patients. The molecular mechanisms of CIPN are incompletely understood and there are no effective preventive or therapeutic measures available to date. Here, we present a brief overview of the current knowledge about mechanisms underlying CIPN and discuss DNA damage-related stress responses as feasible targets for the prevention of CIPN. In addition, we discuss that the nematode Caenorhabditis elegans is a useful 3R-conform model organism to further elucidate molecular mechanisms of CIPN and to identify novel lead compounds protecting from cAT-triggered neuropathy.
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Brinkmann V., Fritz G. Prevention of anticancer therapy-induced neurotoxicity: Putting DNA damage in perspective // NeuroToxicology. 2022. Vol. 91. pp. 1-10.
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Brinkmann V., Fritz G. Prevention of anticancer therapy-induced neurotoxicity: Putting DNA damage in perspective // NeuroToxicology. 2022. Vol. 91. pp. 1-10.
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TY - JOUR
DO - 10.1016/j.neuro.2022.04.009
UR - https://doi.org/10.1016/j.neuro.2022.04.009
TI - Prevention of anticancer therapy-induced neurotoxicity: Putting DNA damage in perspective
T2 - NeuroToxicology
AU - Brinkmann, Vanessa
AU - Fritz, Gerhard
PY - 2022
DA - 2022/07/01
PB - Elsevier
SP - 1-10
VL - 91
SN - 0161-813X
SN - 1872-9711
ER -
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@article{2022_Brinkmann,
author = {Vanessa Brinkmann and Gerhard Fritz},
title = {Prevention of anticancer therapy-induced neurotoxicity: Putting DNA damage in perspective},
journal = {NeuroToxicology},
year = {2022},
volume = {91},
publisher = {Elsevier},
month = {jul},
url = {https://doi.org/10.1016/j.neuro.2022.04.009},
pages = {1--10},
doi = {10.1016/j.neuro.2022.04.009}
}