Open Access

Molecular Therapy - Nucleic Acids, volume 21, pages 192-204

Aptamers Against Live Targets: Is In Vivo SELEX Finally Coming to the Edge?

Mayte Sola ¹

Ashwathi Puravankara Menon ¹

B. Moreno ¹

Daniel Meraviglia Crivelli ¹

Mario M. Soldevilla ¹

Fernando Cartón Garcia ¹

Fernando Pastor ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Molecular Therapeutics Program, Center for Applied Medical Research, CIMA, University of Navarra, Pamplona 31008, Spain |

Publication type: Journal Article

Publication date: 2020-09-01

Elsevier

Journal: Molecular Therapy - Nucleic Acids

Quartile SCImago

Quartile WOS

Impact factor: 8.8

ISSN: 21622531, 21622531

DOI: 10.1016/j.omtn.2020.05.025

Copy DOI

Drug Discovery

Molecular Medicine

Abstract

Targeted therapeutics underwent a revolution with the entry of monoclonal antibodies in the medical toolkit. Oligonucleotide aptamers form another family of target agents that have been lagging behind in reaching the clinical arena in spite of their potential clinical translation. Some of the reasons for this might be related to the challenge in identifying aptamers with optimal in vivo specificity, and the nature of their pharmacokinetics. Aptamers usually show exquisite specificity, but they are also molecules that display dynamic structures subject to changing environments. Temperature, ion atmosphere, pH, and other variables are factors that could determine the affinity and specificity of aptamers. Thus, it is important to tune the aptamer selection process to the conditions in which you want your final aptamer to function; ideally, for in vivo applications, aptamers should be selected in an in vivo-like system or, ultimately, in a whole in vivo organism. In this review we recapitulate the implementations in systematic evolution of ligands by exponential enrichment (SELEX) to obtain aptamers with the best in vivo activity.

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Citations by publishers

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Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 16, 21.05% Multidisciplinary Digital Publishing Institute (MDPI) 16 publications, 21.05%
Elsevier	Elsevier, 15, 19.74% Elsevier 15 publications, 19.74%
Springer Nature	Springer Nature, 6, 7.89% Springer Nature 6 publications, 7.89%
American Chemical Society (ACS)	American Chemical Society (ACS), 6, 7.89% American Chemical Society (ACS) 6 publications, 7.89%
Wiley	Wiley, 5, 6.58% Wiley 5 publications, 6.58%
Frontiers Media S.A.	Frontiers Media S.A., 4, 5.26% Frontiers Media S.A. 4 publications, 5.26%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 3, 3.95% Royal Society of Chemistry (RSC) 3 publications, 3.95%
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Open Exploration Publishing	Open Exploration Publishing, 2, 2.63% Open Exploration Publishing 2 publications, 2.63%
American Scientific Publishers	American Scientific Publishers, 1, 1.32% American Scientific Publishers 1 publication, 1.32%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 1.32% Public Library of Science (PLoS) 1 publication, 1.32%
American Society for Microbiology	American Society for Microbiology, 1, 1.32% American Society for Microbiology 1 publication, 1.32%
IntechOpen	IntechOpen, 1, 1.32% IntechOpen 1 publication, 1.32%
eLife Sciences Publications	eLife Sciences Publications, 1, 1.32% eLife Sciences Publications 1 publication, 1.32%
Future Medicine	Future Medicine, 1, 1.32% Future Medicine 1 publication, 1.32%
Thieme	Thieme, 1, 1.32% Thieme 1 publication, 1.32%
Bentham Science	Bentham Science, 1, 1.32% Bentham Science 1 publication, 1.32%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 1.32% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 1.32%
	2 4 6 8 10 12 14 16

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Sola M. et al. Aptamers Against Live Targets: Is In Vivo SELEX Finally Coming to the Edge? // Molecular Therapy - Nucleic Acids. 2020. Vol. 21. pp. 192-204.

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Sola M., Menon A. P., Moreno B., Meraviglia Crivelli D., Soldevilla M. M., Cartón Garcia F., Pastor F. Aptamers Against Live Targets: Is In Vivo SELEX Finally Coming to the Edge? // Molecular Therapy - Nucleic Acids. 2020. Vol. 21. pp. 192-204.

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