Photodiagnosis and Photodynamic Therapy, volume 34, pages 102215

Combination of 5-Aminolevulinic acid photodynamic therapy and isotretinoin to treat moderate-to-severe acne.

Liu Lin

Liu Peng

Guo Wei

Meng Liya

Zhang Chun Min

Zhang Chunhong

Publication type: Journal Article

Publication date: 2021-06-01

Elsevier

Journal: Photodiagnosis and Photodynamic Therapy

Quartile SCImago

Quartile WOS

Impact factor: 3.3

ISSN: 15721000

DOI: 10.1016/j.pdpdt.2021.102215

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Oncology

Biophysics

Pharmacology (medical)

Dermatology

Abstract

• Combined photodynamic therapy has been widely used for moderate-severe acne.However,PDT combined with isotretinoin is rarely reported. • PDT combined with low-dose isotretinoin in the treatment of moderate-severe acne had higher efficacy,lower recurrence rate and good tolerance. • This study provides a clinical basis for the use of photodynamic therapy combined with isotretinoin for moderate-severe acne. In China, photodynamic therapy(PDT) has been widely accepted in the treatment of acne. However, there are few studies on PDT combined with isotretinoin of moderate to severe acne. To evaluate the efficacy and safety of PDT combined with isotretinoin in the treatment of moderate to severe acne. 70 cases of moderate and severe acne patients were randomly divided into PDT group and combination group. In combination group, patients were treated with PDT, once/2weeks, for 3 times; and oral isotretinoin, 10 mg twice a day for 3 months. The PDT group was treated with PDT alone. The skin lesions were counted before treatment and in the 4th, 6th, 8th, and 12th weeks to evaluate the clinical efficacy. Adverse reactions during the treatment were recorded. We monitored the liver function of the combination group once a month. The recurrence rate was recorded 6 months after treatment. A total of 67 patients completed the study. The effective rates of combination group in the 4th, 6th, 8th, and 12th weeks of treatment were 28.6 %, 71.4 %, 91.4 %, and 94.1 %, respectively; the effective rates of PDT group in the 4th, 6th, 8th, and 12th weeks of treatment were 22.9 %, 54.3 %, 74.3 %, and 78.8 %, respectively; the effective rates of two groups were statistically significant in the 6th, 8th, and 12th weeks of treatment (P < 0.05). There was no significant difference in pain score between two groups during the photodynamic therapy(P＞0.05). Adverse reactions, such as erythema and pustule during photodynamic therapy in both groups were tolerable. The pigmentation subsided in about 3 months. The recurrence rate of combination group was significantly lower than that of PDT group(7% VS 24 %,P＜0.05). PDT combined with isotretinoin has higher effective rate and lower recurrence rate than single PDT, and is a choice for the treatment of moderate to severe acne.

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Citations by journals

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Journal of Cosmetic Dermatology	Journal of Cosmetic Dermatology, 3, 37.5% Journal of Cosmetic Dermatology 3 publications, 37.5%
Dyes and Pigments	Dyes and Pigments, 1, 12.5% Dyes and Pigments 1 publication, 12.5%
Journal of Clinical Medicine	Journal of Clinical Medicine, 1, 12.5% Journal of Clinical Medicine 1 publication, 12.5%
Frontiers in Medicine	Frontiers in Medicine, 1, 12.5% Frontiers in Medicine 1 publication, 12.5%
Clinical, Cosmetic and Investigational Dermatology	Clinical, Cosmetic and Investigational Dermatology, 1, 12.5% Clinical, Cosmetic and Investigational Dermatology 1 publication, 12.5%
Journal of Cutaneous Medicine and Surgery	Journal of Cutaneous Medicine and Surgery, 1, 12.5% Journal of Cutaneous Medicine and Surgery 1 publication, 12.5%
	1 2 3

Citations by publishers

	1 2 3
Wiley	Wiley, 3, 37.5% Wiley 3 publications, 37.5%
Elsevier	Elsevier, 1, 12.5% Elsevier 1 publication, 12.5%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 1, 12.5% Multidisciplinary Digital Publishing Institute (MDPI) 1 publication, 12.5%
Frontiers Media S.A.	Frontiers Media S.A., 1, 12.5% Frontiers Media S.A. 1 publication, 12.5%
Dove Medical Press	Dove Medical Press, 1, 12.5% Dove Medical Press 1 publication, 12.5%
SAGE	SAGE, 1, 12.5% SAGE 1 publication, 12.5%
	1 2 3

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Liu L. et al. Combination of 5-Aminolevulinic acid photodynamic therapy and isotretinoin to treat moderate-to-severe acne. // Photodiagnosis and Photodynamic Therapy. 2021. Vol. 34. p. 102215.

GOST all authors (up to 50) Copy

Liu L., Liu P., Guo W., Meng L., Zhang C. M., Zhang C. Combination of 5-Aminolevulinic acid photodynamic therapy and isotretinoin to treat moderate-to-severe acne. // Photodiagnosis and Photodynamic Therapy. 2021. Vol. 34. p. 102215.

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RIS Copy

TY - JOUR

DO - 10.1016/j.pdpdt.2021.102215

UR - https://doi.org/10.1016%2Fj.pdpdt.2021.102215

TI - Combination of 5-Aminolevulinic acid photodynamic therapy and isotretinoin to treat moderate-to-severe acne.

T2 - Photodiagnosis and Photodynamic Therapy

AU - Liu, Lin

AU - Liu, Peng

AU - Guo, Wei

AU - Meng, Liya

AU - Zhang, Chun Min

AU - Zhang, Chunhong

PY - 2021

DA - 2021/06/01 00:00:00

PB - Elsevier

SP - 102215

VL - 34

SN - 1572-1000

ER -

BibTex

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BibTex Copy

@article{2021_Liu,

author = {Lin Liu and Peng Liu and Wei Guo and Liya Meng and Chun Min Zhang and Chunhong Zhang},

title = {Combination of 5-Aminolevulinic acid photodynamic therapy and isotretinoin to treat moderate-to-severe acne.},

journal = {Photodiagnosis and Photodynamic Therapy},

year = {2021},

volume = {34},

publisher = {Elsevier},

month = {jun},

url = {https://doi.org/10.1016%2Fj.pdpdt.2021.102215},

pages = {102215},

doi = {10.1016/j.pdpdt.2021.102215}

}

Found error?

Publisher

Elsevier

Journal

Photodiagnosis and Photodynamic Therapy

Quartile SCImago

Quartile WOS

Impact factor

3.3

ISSN

15721000 (Print)