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том 52 издание 4 страницы 302-306

COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis.

Тип публикацииJournal Article
Дата публикации2005-10-01
scimago Q1
wos Q1
БС1
SJR2.664
CiteScore18.6
Impact factor10.5
ISSN10436618, 10961186
Pharmacology
Краткое описание
We report on the inhibitory activity of the NSAIDs meloxicam, carprofen, phenylbutazone and flunixin, on blood cyclooxygenases in the horse using in vitro enzyme-linked assays. As expected, comparison of IC50 indicated that meloxicam and carprofen are more selective inhibitors of COX-2 than phenylbutazone and flunixin; meloxicam was the most advantageous for horses of four NSAIDs examined. However at IC80, phenylbutazone (+134.4%) and flunixin (+29.7%) had greater COX-2 selectivity than at IC50, and meloxicam (-41.2%) and carprofen (-12.9%) had lower COX-2 selectivity than at IC50. We therefore propose that the selectivity of NSAIDs should be assessed at the 80% as well as 50% inhibition level.
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Beretta C., Garavaglia G., Cavalli M. COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis. // Pharmacological Research. 2005. Vol. 52. No. 4. pp. 302-306.
ГОСТ со всеми авторами (до 50) Скопировать
Beretta C., Garavaglia G., Cavalli M. COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis. // Pharmacological Research. 2005. Vol. 52. No. 4. pp. 302-306.
RIS |
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TY - JOUR
DO - 10.1016/j.phrs.2005.04.004
UR - https://doi.org/10.1016/j.phrs.2005.04.004
TI - COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis.
T2 - Pharmacological Research
AU - Beretta, C.
AU - Garavaglia, G
AU - Cavalli, M.
PY - 2005
DA - 2005/10/01
PB - Elsevier
SP - 302-306
IS - 4
VL - 52
PMID - 15939622
SN - 1043-6618
SN - 1096-1186
ER -
BibTex |
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BibTex (до 50 авторов) Скопировать
@article{2005_Beretta,
author = {C. Beretta and G Garavaglia and M. Cavalli},
title = {COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis.},
journal = {Pharmacological Research},
year = {2005},
volume = {52},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.phrs.2005.04.004},
number = {4},
pages = {302--306},
doi = {10.1016/j.phrs.2005.04.004}
}
MLA
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Beretta, C., et al. “COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis..” Pharmacological Research, vol. 52, no. 4, Oct. 2005, pp. 302-306. https://doi.org/10.1016/j.phrs.2005.04.004.