Radiation Physics and Chemistry, volume 184, pages 109435
Degradation mechanism of losartan in aqueous solutions under the effect of gamma radiation
1
National Center for Nuclear Sciences and Technologies, Sidi Thabet Technopark, 2020, Ariana, Tunisia
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Publication type: Journal Article
Publication date: 2021-07-01
Journal:
Radiation Physics and Chemistry
Quartile SCImago
Q2
Quartile WOS
Q1
Impact factor: 2.9
ISSN: 0969806X
Radiation
Abstract
In this paper, the impact of gamma radiation on one of emerging pharmaceutical pollutant was investigated. Deriving from sartan class, losartan, one of the most consumed antihypertensive drug was irradiated at doses of 0.5–4 kGy in aqueous solutions. The removal of chemical oxygen demand (COD) and total organic carbon (TOC) during the irradiation process reflects that the mineralization efficiency increases with increasing radiation dose. During the mineralization process some aromatic intermediates such as 4-[2-(1H-1,2,3,4-tetrazol-5-yl) phenyl] phenol, 2-butyl-4-chloro-5-(hydroxymethyl) imidazole-1-ol, 2,4′-dihydroxybiphenyl, tetrazole, 1,2,4 benzentriol, 1,4-hydroxyquinone and quinone were identified by LC/MS. These results show that degradation process starts with cleavage of the starting molecule by hydroxyl radicals, which are generated by the radiolysis of water. Based on these observations, a mechanistic schema of losartan was proposed. At the end, losartan kinetic study was performed indicating a pseudo first order degradation process.
Top-30
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Citations by publishers
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1
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Springer Nature
2 publications, 22.22%
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Taylor & Francis
2 publications, 22.22%
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Elsevier
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Walter de Gruyter
1 publication, 11.11%
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 11.11%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 11.11%
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- We do not take into account publications without a DOI.
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- Statistics recalculated weekly.
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Zaouak A., Noomen A., Jelassi H. Degradation mechanism of losartan in aqueous solutions under the effect of gamma radiation // Radiation Physics and Chemistry. 2021. Vol. 184. p. 109435.
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Zaouak A., Noomen A., Jelassi H. Degradation mechanism of losartan in aqueous solutions under the effect of gamma radiation // Radiation Physics and Chemistry. 2021. Vol. 184. p. 109435.
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TY - JOUR
DO - 10.1016/j.radphyschem.2021.109435
UR - https://doi.org/10.1016/j.radphyschem.2021.109435
TI - Degradation mechanism of losartan in aqueous solutions under the effect of gamma radiation
T2 - Radiation Physics and Chemistry
AU - Zaouak, Amira
AU - Noomen, Ahlem
AU - Jelassi, Haikel
PY - 2021
DA - 2021/07/01 00:00:00
PB - Elsevier
SP - 109435
VL - 184
SN - 0969-806X
ER -
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@article{2021_Zaouak,
author = {Amira Zaouak and Ahlem Noomen and Haikel Jelassi},
title = {Degradation mechanism of losartan in aqueous solutions under the effect of gamma radiation},
journal = {Radiation Physics and Chemistry},
year = {2021},
volume = {184},
publisher = {Elsevier},
month = {jul},
url = {https://doi.org/10.1016/j.radphyschem.2021.109435},
pages = {109435},
doi = {10.1016/j.radphyschem.2021.109435}
}