A continuous protocol for the epoxidation of olefins, monocyclic terpenes, and Alpha Beta Unsaturated Carbonyl Synthons using eco-friendly Flow Reactor Conditions

Herein, we report a simple synthetic protocol for selective epoxidation of olefins, monocyclic terpenes, and chalcones using a continuous semi-batch process in good to excellent yields. Mainly, industrial semi-batch epoxidation is an extremely risky process that includes very high safety measures to avoid the accumulation of peroxide species in the reactor during the process, which leads to accidents. To avoid the same, we have established a constant flow reactor protocol for the epoxidation of fore mentioned key synthons using a cyanamide-potassium carbonate catalytic system which helps to reduce the accumulation of the peroxide species, and also yields moderate to high yields of the desired products. The developed methodology was successfully utilized for the epoxidation of a range of aliphatic to aromatic olefins to generate corresponding epoxides. All the products and their structures were examined using 1 HNMR, and 13 NMR spectroscopy. More importantly, this proposed protocol is recyclable and reproducible where in using similar research conditions. • Organ catalytic epoxidation reactions have now reached a level of interest to provide a process review highlighting the multi substrate epoxidation using flow chemistry. • Industrial semi-batch epoxidation is an extremely risky process to avoid the accumulation of the peroxide species within the reactor during the process, which leads to accidents. • We have developed a simple, and continuous protocol for the epoxidation of Olefins, other synthons in high yields using cyanamide-Potassium carbonate flow reactor system to reduce the accumulation of the peroxide species. • All the prepared epoxy synthons are analytically pure such as 1 H, and 13 C-NMRs.