Interaction of amphiphilic drugs with human and bovine serum albumins
Тип публикации: Journal Article
Дата публикации: 2012-11-01
scimago Q2
wos Q1
БС1
SJR: 0.664
CiteScore: 8.5
Impact factor: 4.6
ISSN: 13861425, 18733557
PubMed ID:
22750346
Spectroscopy
Analytical Chemistry
Atomic and Molecular Physics, and Optics
Instrumentation
Краткое описание
To know the interaction of amphiphilic drugs nortriptyline hydrochloride (NOT) and promazine hydrochloride (PMZ) with serum albumins (i.e., human serum albumin (HSA) and bovine serum albumin (BSA)), techniques of UV-visible, fluorescence, and circular dichroism (CD) spectroscopies are used. The binding affinity is more in case of PMZ with both the serum albumins. The quenching rate constant (k(q)) values suggest a static quenching process for all the drug-serum albumin interactions. The UV-visible results show that the change in protein conformation of PMZ-serum albumin interactions are more prominent as compared to NOT-serum albumin interactions. The CD results also explain the conformational changes in the serum albumins on binding with the drugs. The increment in %α-helical structure is slightly more for drug-BSA complexes as compared to drug-HSA complexes.
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ГОСТ
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Khan A. B. et al. Interaction of amphiphilic drugs with human and bovine serum albumins // Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy. 2012. Vol. 97. pp. 119-124.
ГОСТ со всеми авторами (до 50)
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Khan A. B., Khan J. M., Ali M. T., Khan R., Kabir-ud-Din Interaction of amphiphilic drugs with human and bovine serum albumins // Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy. 2012. Vol. 97. pp. 119-124.
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TY - JOUR
DO - 10.1016/j.saa.2012.05.060
UR - https://doi.org/10.1016/j.saa.2012.05.060
TI - Interaction of amphiphilic drugs with human and bovine serum albumins
T2 - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
AU - Khan, Abbul Bashar
AU - Khan, Javed M.
AU - Ali, Mohd Tarmizi
AU - Khan, Rizwan
AU - Kabir-ud-Din
PY - 2012
DA - 2012/11/01
PB - Elsevier
SP - 119-124
VL - 97
PMID - 22750346
SN - 1386-1425
SN - 1873-3557
ER -
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@article{2012_Khan,
author = {Abbul Bashar Khan and Javed M. Khan and Mohd Tarmizi Ali and Rizwan Khan and Kabir-ud-Din},
title = {Interaction of amphiphilic drugs with human and bovine serum albumins},
journal = {Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy},
year = {2012},
volume = {97},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.saa.2012.05.060},
pages = {119--124},
doi = {10.1016/j.saa.2012.05.060}
}