Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, volume 238, pages 118433
Stability indicating spectrophotometric methods for quantitative determination of bromazepam and its degradation product
Hany W. Darwish
1, 2
,
Nesma A Ali
3
,
Ibrahim A. Naguib
4, 5
,
Mohamed R El Ghobashy
6
,
Abdullah M Al Hossaini
7
,
Nada S. Abdelwahab
8
3
Toxicology Laboratory, Forensic Medicine Authority, Justice Ministry,114 Bairam El Tounsy St., El Sayeda Zeinab, 11647 Cairo, Egypt
|
5
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Alshaheed Shehata Ahmad Hegazy St., 62514 Beni-Suef, Egypt
|
8
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Alshaheed Shehata Ahmad Hegazy St, 62514, Beni-Suef, Egypt
|
Publication type: Journal Article
Publication date: 2020-09-01
Quartile SCImago
Q2
Quartile WOS
Q1
Impact factor: 4.4
ISSN: 13861425
Spectroscopy
Analytical Chemistry
Atomic and Molecular Physics, and Optics
Instrumentation
Abstract
Four simple, sensitive and selective stability indicating spectrophotometric methods are presented for quantitative determination of the benzodiazepine drug; bromazepam (BMZ) and one of its reported potential impurities and degradation product; 2-(2-amino-5-bromobenzoyl) pyridine (ABP) in methanol. Method A, is isoabsorptive point coupled with D0 method, where good linearity was obtained by measuring the absorbance of BMZ at 264 nm (Aiso) in the concentration range of 2–25 μg mL−1, and the absorbance of ABP at its λmax 396 nm in concentration range of 0.5–24 μg mL−1. Method B, is ratio subtraction; the absorbance was measured at 233 nm for BMZ using 20 μg mL−1 of ABP, while ABP was determined directly at its λmax 396 nm using methanol as a solvent. Method C, was based on measuring the total peak amplitude of the first derivative of the ratio spectra (DD1) of BMZ from 301 to 326 nm using 10 μg mL−1 of ABP as a divisor and determination of ABP at peak amplitude of 293 nm using 5 μg mL−1 of BMZ as a divisor. In method D, ratio difference method, good linearity was achieved for determination of BMZ and ABP by measuring the differences between the amplitudes of ratio spectra at 312 nm and 274 nm and differences between the amplitudes of ratio spectra at 274 nm and 312 nm, respectively. The stability of BMZ was investigated under different ICH recommended forced degradation conditions. The suggested methods were then successfully applied for determination of BMZ in its pharmaceutical formulations.
Top-30
Citations by journals
1
|
|
Journal of Molecular Liquids
1 publication, 12.5%
|
|
Chemosensors
1 publication, 12.5%
|
|
Molecules
1 publication, 12.5%
|
|
Journal of Drug Delivery Science and Technology
1 publication, 12.5%
|
|
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
1 publication, 12.5%
|
|
PLoS ONE
1 publication, 12.5%
|
|
Polymers
1 publication, 12.5%
|
|
Journal of Applied Spectroscopy
1 publication, 12.5%
|
|
1
|
Citations by publishers
1
2
3
|
|
Elsevier
3 publications, 37.5%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
3 publications, 37.5%
|
|
Public Library of Science (PLoS)
1 publication, 12.5%
|
|
Springer Nature
1 publication, 12.5%
|
|
1
2
3
|
- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2021,2022,2023],"ids":[0,0,0],"codes":[0,0,0],"imageUrls":["","",""],"datasets":[{"label":"Citations number","data":[2,4,2],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6"],"percentage":["25","50","25"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Journal of Molecular Liquids","Chemosensors","Molecules","Journal of Drug Delivery Science and Technology","Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy","PLoS ONE","Polymers","Journal of Applied Spectroscopy"],"ids":[13597,2627,1770,17907,6337,24963,11204,21731],"codes":[0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp"],"datasets":[{"label":"","data":[1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[12.5,12.5,12.5,12.5,12.5,12.5,12.5,12.5],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Multidisciplinary Digital Publishing Institute (MDPI)","Public Library of Science (PLoS)","Springer Nature"],"ids":[17,202,344,8],"codes":[0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp"],"datasets":[{"label":"","data":[3,3,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[37.5,37.5,12.5,12.5],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartiles":{"type":"bar","data":{"show":true,"labels":[2021,2022,2023],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,0,1],"percentage":["0","0","12.5"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[0,0,0],"percentage":["0","0","0"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[0,2,0],"percentage":["0","25","0"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[2,2,1],"percentage":["25","25","12.5"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[0,0,0],"percentage":["0","0","0"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by SCImago per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartilesWs":{"type":"bar","data":{"show":true,"labels":[2021,2022,2023],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,0,1],"percentage":["0","0","12.5"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[0,0,0],"percentage":["0","0","0"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[1,2,0],"percentage":["12.5","25","0"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[1,2,1],"percentage":["12.5","25","12.5"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[0,0,0],"percentage":["0","0","0"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by WoS per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
Darwish H. W. et al. Stability indicating spectrophotometric methods for quantitative determination of bromazepam and its degradation product // Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy. 2020. Vol. 238. p. 118433.
GOST all authors (up to 50)
Copy
Darwish H. W., Ali N. A., Naguib I. A., El Ghobashy M. R., Al Hossaini A. M., Abdelwahab N. S. Stability indicating spectrophotometric methods for quantitative determination of bromazepam and its degradation product // Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy. 2020. Vol. 238. p. 118433.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.saa.2020.118433
UR - https://linkinghub.elsevier.com/retrieve/pii/S138614252030411X
TI - Stability indicating spectrophotometric methods for quantitative determination of bromazepam and its degradation product
T2 - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
AU - Darwish, Hany W.
AU - Ali, Nesma A
AU - Naguib, Ibrahim A.
AU - El Ghobashy, Mohamed R
AU - Al Hossaini, Abdullah M
AU - Abdelwahab, Nada S.
PY - 2020
DA - 2020/09/01 00:00:00
PB - Elsevier
SP - 118433
VL - 238
SN - 1386-1425
ER -
Cite this
BibTex
Copy
@article{2020_Darwish,
author = {Hany W. Darwish and Nesma A Ali and Ibrahim A. Naguib and Mohamed R El Ghobashy and Abdullah M Al Hossaini and Nada S. Abdelwahab},
title = {Stability indicating spectrophotometric methods for quantitative determination of bromazepam and its degradation product},
journal = {Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy},
year = {2020},
volume = {238},
publisher = {Elsevier},
month = {sep},
url = {https://linkinghub.elsevier.com/retrieve/pii/S138614252030411X},
pages = {118433},
doi = {10.1016/j.saa.2020.118433}
}
Profiles