A comprehensive review on toxicological mechanisms and transformation products of tebuconazole: Insights on pesticide management

Tebuconazole has been widely applied over three decades because of its high efficiency, low toxicity, and broad spectrum, and it is still one of the most popular fungicides worldwide. Tebuconazole residues have been frequently detected in environmental samples and food, posing potential hazards for humans. Understanding the toxicity of pesticides is crucial to ensuring human and ecosystem health, but the toxic mechanisms and toxicity of tebuconazole are still unclear. Moreover, pesticides could transform into transformation products (TPs) that may be more persistent and toxic than their parents. Herein, the toxicities of tebuconazole to humans, mammals, aquatic organisms, soil animals, amphibians, soil microorganisms, birds, honeybees, and plants were summarized, and its TPs were reviewed. In addition, the toxicity of tebuconazole TPs to aquatic organisms and mammals was predicted. Tebuconazole posed potential developmental toxicity, genotoxicity, reproductive toxicity, mutagenicity, hepatotoxicity, neurotoxicity, cardiotoxicity, and nephrotoxicity, which were induced via reactive oxygen species-mediated apoptosis, metabolism and hormone perturbation, DNA damage, and transcriptional abnormalities. In addition, tebuconazole exhibited apparent endocrine-disrupting effects by modulating hormone levels and gene transcription. The toxicity of some TPs was equivalent to and higher than tebuconazole. Therefore, further investigation is necessary into the toxicological mechanisms of tebuconazole and the combined toxicity of a mixture of tebuconazole and its TPs.