Sensors and Actuators, B: Chemical, volume 355, pages 131324

SERS-based dual-mode DNA aptasensors for rapid classification of SARS-CoV-2 and influenza A/H1N1 infection

Hao Chen ¹

Sungkyu Park ²

Younju Joung ¹

Taejoon Kang ³

Mikyung Lee ⁴

Jaebum Choo ¹

Hide authors affiliations Show authors affiliations: 4 affiliations

Department of Chemistry, Chung-Ang University, Seoul 06974, South Korea |

Nano-Bio Convergence Department, Korea Institute of Materials Science (KIMS), Changwon 51508, South Korea |

Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, South Korea |

⁴

Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul 06973, South Korea |

Publication type: Journal Article

Publication date: 2022-03-01

Elsevier

Journal: Sensors and Actuators, B: Chemical

Quartile SCImago

Quartile WOS

Impact factor: 8.4

ISSN: 09254005

DOI: 10.1016/j.snb.2021.131324

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PubMed ID: 34987275

Materials Chemistry

Metals and Alloys

Surfaces, Coatings and Films

Electronic, Optical and Magnetic Materials

Condensed Matter Physics

Electrical and Electronic Engineering

Instrumentation

Abstract

We developed a dual-mode surface-enhanced Raman scattering (SERS)-based aptasensor that can accurately diagnose and distinguish severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A/H1N1 at the same time. Herein, DNA aptamers that selectively bind to SARS-CoV-2 and influenza A/H1N1 were immobilized together on Au nanopopcorn substrate. Raman reporters (Cy3 and RRX), attached to the terminal of DNA aptamers, could generate strong SERS signals in the nanogap of the Au nanopopcorn substrate. Additionally, the internal standard Raman reporter (4-MBA) was immobilized on the Au nanopopcorn substrate along with aptamer DNAs to reduce errors caused by changes in the measurement environment. When SARS-CoV-2 or influenza A virus approaches the Au nanopopcorn substrate, the corresponding DNA aptamer selectively detaches from the substrate due to the significant binding affinity between the corresponding DNA aptamer and the virus. As a result, the related SERS intensity decreases with increasing target virus concentration. Thus, it is possible to determine whether a suspected patient is infected with SARS-CoV-2 or influenza A using this SERS-based DNA aptasensor. Furthermore, this sensor enables a quantitative evaluation of the target virus concentration with high sensitivity without being affected by cross-reactivity. Therefore, this SERS-based diagnostic platform is considered a conceptually new diagnostic tool that rapidly discriminates against these two respiratory diseases to prevent their spread. • A dual-mode SERS-based DNA aptasensor to diagnose two viruses has been developed. • DNA aptamers-immobilized on Au nanopopcorn substrate was used as a sensing template. • This sensor enables rapid differentiation between SARS-CoV-2 and influenza A infection.

By date By citations

Top-30

Citations by journals

	1 2 3 4 5 6
Analytica Chimica Acta	Analytica Chimica Acta, 6, 16.22% Analytica Chimica Acta 6 publications, 16.22%
Biosensors	Biosensors, 3, 8.11% Biosensors 3 publications, 8.11%
Sensors and Actuators, B: Chemical	Sensors and Actuators, B: Chemical, 3, 8.11% Sensors and Actuators, B: Chemical 3 publications, 8.11%
Bulletin of the Korean Chemical Society	Bulletin of the Korean Chemical Society, 2, 5.41% Bulletin of the Korean Chemical Society 2 publications, 5.41%
Microchimica Acta	Microchimica Acta, 2, 5.41% Microchimica Acta 2 publications, 5.41%
Talanta	Talanta, 2, 5.41% Talanta 2 publications, 5.41%
Frontiers in Chemistry	Frontiers in Chemistry, 1, 2.7% Frontiers in Chemistry 1 publication, 2.7%
ACS Sensors	ACS Sensors, 1, 2.7% ACS Sensors 1 publication, 2.7%
Pharmaceuticals	Pharmaceuticals, 1, 2.7% Pharmaceuticals 1 publication, 2.7%
Frontiers in Bioengineering and Biotechnology	Frontiers in Bioengineering and Biotechnology, 1, 2.7% Frontiers in Bioengineering and Biotechnology 1 publication, 2.7%
Nanomaterials	Nanomaterials, 1, 2.7% Nanomaterials 1 publication, 2.7%
International Journal of Surgery	International Journal of Surgery, 1, 2.7% International Journal of Surgery 1 publication, 2.7%
Trends in Biotechnology	Trends in Biotechnology, 1, 2.7% Trends in Biotechnology 1 publication, 2.7%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 2.7% International Journal of Molecular Sciences 1 publication, 2.7%
Influenza and other Respiratory Viruses	Influenza and other Respiratory Viruses, 1, 2.7% Influenza and other Respiratory Viruses 1 publication, 2.7%
ACS applied materials & interfaces	ACS applied materials & interfaces, 1, 2.7% ACS applied materials & interfaces 1 publication, 2.7%
Sensors & Diagnostics	Sensors & Diagnostics, 1, 2.7% Sensors & Diagnostics 1 publication, 2.7%
Journal of Raman Spectroscopy	Journal of Raman Spectroscopy, 1, 2.7% Journal of Raman Spectroscopy 1 publication, 2.7%
BMEMat	BMEMat, 1, 2.7% BMEMat 1 publication, 2.7%
Discover Nano	Discover Nano, 1, 2.7% Discover Nano 1 publication, 2.7%
Infectious Diseases	Infectious Diseases, 1, 2.7% Infectious Diseases 1 publication, 2.7%
Analytical and Bioanalytical Chemistry	Analytical and Bioanalytical Chemistry, 1, 2.7% Analytical and Bioanalytical Chemistry 1 publication, 2.7%
Russian Chemical Reviews	Russian Chemical Reviews, 1, 2.7% Russian Chemical Reviews 1 publication, 2.7%
Nano Energy	Nano Energy, 1, 2.7% Nano Energy 1 publication, 2.7%
	1 2 3 4 5 6

Citations by publishers

	2 4 6 8 10 12 14
Elsevier	Elsevier, 14, 37.84% Elsevier 14 publications, 37.84%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 6, 16.22% Multidisciplinary Digital Publishing Institute (MDPI) 6 publications, 16.22%
Wiley	Wiley, 5, 13.51% Wiley 5 publications, 13.51%
Springer Nature	Springer Nature, 4, 10.81% Springer Nature 4 publications, 10.81%
Frontiers Media S.A.	Frontiers Media S.A., 2, 5.41% Frontiers Media S.A. 2 publications, 5.41%
American Chemical Society (ACS)	American Chemical Society (ACS), 2, 5.41% American Chemical Society (ACS) 2 publications, 5.41%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 2.7% Royal Society of Chemistry (RSC) 1 publication, 2.7%
Taylor & Francis	Taylor & Francis, 1, 2.7% Taylor & Francis 1 publication, 2.7%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 2.7% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 2.7%
	2 4 6 8 10 12 14

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
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Chen H. et al. SERS-based dual-mode DNA aptasensors for rapid classification of SARS-CoV-2 and influenza A/H1N1 infection // Sensors and Actuators, B: Chemical. 2022. Vol. 355. p. 131324.

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Chen H., Park S., Joung Y., Kang T., Lee M., Choo J. SERS-based dual-mode DNA aptasensors for rapid classification of SARS-CoV-2 and influenza A/H1N1 infection // Sensors and Actuators, B: Chemical. 2022. Vol. 355. p. 131324.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.snb.2021.131324

UR - https://linkinghub.elsevier.com/retrieve/pii/S092540052101892X

TI - SERS-based dual-mode DNA aptasensors for rapid classification of SARS-CoV-2 and influenza A/H1N1 infection

T2 - Sensors and Actuators, B: Chemical

AU - Chen, Hao

AU - Park, Sungkyu

AU - Joung, Younju

AU - Kang, Taejoon

AU - Lee, Mikyung

AU - Choo, Jaebum

PY - 2022

DA - 2022/03/01 00:00:00

PB - Elsevier

SP - 131324

VL - 355

PMID - 34987275

SN - 0925-4005

ER -

BibTex

Cite this

BibTex Copy

@article{2022_Chen,

author = {Hao Chen and Sungkyu Park and Younju Joung and Taejoon Kang and Mikyung Lee and Jaebum Choo},

title = {SERS-based dual-mode DNA aptasensors for rapid classification of SARS-CoV-2 and influenza A/H1N1 infection},

journal = {Sensors and Actuators, B: Chemical},

year = {2022},

volume = {355},

publisher = {Elsevier},

month = {mar},

url = {https://linkinghub.elsevier.com/retrieve/pii/S092540052101892X},

pages = {131324},

doi = {10.1016/j.snb.2021.131324}

}

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Publisher

Elsevier

Journal

Sensors and Actuators, B: Chemical

Quartile SCImago

Quartile WOS

Impact factor

8.4

ISSN

09254005 (Print)

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