Catalytic cyclometallation in steroid chemistry V: Synthesis of hybrid molecules based on steroid oximes and (5Z,9Z)-tetradeca-5,9-dienedioic acid as potential anticancer agents
Publication type: Journal Article
Publication date: 2018-10-01
scimago Q2
wos Q3
SJR: 0.620
CiteScore: 4.3
Impact factor: 2.3
ISSN: 0039128X, 18785867
PubMed ID:
29894723
Organic Chemistry
Biochemistry
Molecular Biology
Pharmacology
Clinical Biochemistry
Endocrinology
Abstract
Synthetic analogues of natural 5Z,9Z-dienoic acids - hybrid molecules based on the oximes of cholesterol, pregnenolone, and androsterone with 1,14-tetradeca-5Z,9Z-dienedicarboxylic acid - were synthesized for the first time and studied for antitumor activity in vitro. The acid was prepared using catalytic cyclomagnesiation of O-containing 1,2-dienes with Grignard reagent in the presence of Cp2TiCl2 as the key step. Using flow cytometry, it was shown for the first time that the new molecules are efficient apoptosis inducers in the HeLa, Hek293, U937, Jurkat, and K562.
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18
Total citations:
18
Citations from 2024:
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(27.78%)
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GOST
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D'yakonov V. A. et al. Catalytic cyclometallation in steroid chemistry V: Synthesis of hybrid molecules based on steroid oximes and (5Z,9Z)-tetradeca-5,9-dienedioic acid as potential anticancer agents // Steroids. 2018. Vol. 138. pp. 14-20.
GOST all authors (up to 50)
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D'yakonov V. A., Tuktarova R. A., Dzhemileva L. U., Ishmukhametova S. R., Yunusbaeva M. M., Dzhemilev U. M. Catalytic cyclometallation in steroid chemistry V: Synthesis of hybrid molecules based on steroid oximes and (5Z,9Z)-tetradeca-5,9-dienedioic acid as potential anticancer agents // Steroids. 2018. Vol. 138. pp. 14-20.
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RIS
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TY - JOUR
DO - 10.1016/j.steroids.2018.06.002
UR - https://doi.org/10.1016/j.steroids.2018.06.002
TI - Catalytic cyclometallation in steroid chemistry V: Synthesis of hybrid molecules based on steroid oximes and (5Z,9Z)-tetradeca-5,9-dienedioic acid as potential anticancer agents
T2 - Steroids
AU - D'yakonov, Vladimir A
AU - Tuktarova, Regina A.
AU - Dzhemileva, Lilya U.
AU - Ishmukhametova, Svetlana R.
AU - Yunusbaeva, Milyausha M.
AU - Dzhemilev, Usein M
PY - 2018
DA - 2018/10/01
PB - Elsevier
SP - 14-20
VL - 138
PMID - 29894723
SN - 0039-128X
SN - 1878-5867
ER -
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BibTex (up to 50 authors)
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@article{2018_D'yakonov,
author = {Vladimir A D'yakonov and Regina A. Tuktarova and Lilya U. Dzhemileva and Svetlana R. Ishmukhametova and Milyausha M. Yunusbaeva and Usein M Dzhemilev},
title = {Catalytic cyclometallation in steroid chemistry V: Synthesis of hybrid molecules based on steroid oximes and (5Z,9Z)-tetradeca-5,9-dienedioic acid as potential anticancer agents},
journal = {Steroids},
year = {2018},
volume = {138},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.steroids.2018.06.002},
pages = {14--20},
doi = {10.1016/j.steroids.2018.06.002}
}
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