Talanta, volume 75, issue 1, pages 239-245
Development and validation of HPLC method for the resolution of drug intermediates: dl-3-Phenyllactic acid, dl-O-acetyl-3-phenyllactic acid and (±)-mexiletine acetamide enantiomers
Publication type: Journal Article
Publication date: 2008-03-15
Analytical Chemistry
Abstract
Sensitive and specific, high-performance liquid chromatography (HPLC) methods have been developed and validated for linearity, accuracy and precision for the quantification of dl-3-phenyllactic acid, dl-O-acetyl-3-phenyllactic acid and (+/-)-mexiletine acetamide enantiomers. Chromatographic separations were performed on a Chiralcel OJ-H column (0.46 mm x 250 mm, 5 microm, Daicel Chemical Industries, Japan) based on cellulose tris-(4-methyl benzoate) chiral stationary phase. The mobile phase consists of hexane and isopropanol (IPA) in the ratio of 90:10 containing 0.1% trifluoroacetic acid (in case of dl-3-phenyllactic acid and dl-O-acetyl-3-phenyllactic acid) and hexane and IPA (95:5) containing 0.1% triethylamine (in case of (+/-)-mexiletine acetamide) and the flow rate was set at 0.5 ml/min at 25 degrees C. The detection was carried out at 261 nm for dl-3-phenyllactic acid and dl-O-acetyl-3-phenyllactic acid and at 254 nm for (+/-)-mexiletine acetamide. The developed methods were utilized for monitoring the progress of lipase catalyzed enantioselective synthesis of O-acetyl-3-phenyllactic acid and mexiletine acetamide from dl-3-phenyllactic acid and (+/-)-mexiletine, respectively.
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Tekewe A. Development and validation of HPLC method for the resolution of drug intermediates: dl-3-Phenyllactic acid, dl-O-acetyl-3-phenyllactic acid and (±)-mexiletine acetamide enantiomers // Talanta. 2008. Vol. 75. No. 1. pp. 239-245.
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Tekewe A. Development and validation of HPLC method for the resolution of drug intermediates: dl-3-Phenyllactic acid, dl-O-acetyl-3-phenyllactic acid and (±)-mexiletine acetamide enantiomers // Talanta. 2008. Vol. 75. No. 1. pp. 239-245.
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TY - JOUR
DO - 10.1016/j.talanta.2007.11.004
UR - https://doi.org/10.1016/j.talanta.2007.11.004
TI - Development and validation of HPLC method for the resolution of drug intermediates: dl-3-Phenyllactic acid, dl-O-acetyl-3-phenyllactic acid and (±)-mexiletine acetamide enantiomers
T2 - Talanta
AU - Tekewe, A
PY - 2008
DA - 2008/03/15 00:00:00
PB - Elsevier
SP - 239-245
IS - 1
VL - 75
SN - 0039-9140
SN - 1873-3573
ER -
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@article{2008_Tekewe,
author = {A Tekewe},
title = {Development and validation of HPLC method for the resolution of drug intermediates: dl-3-Phenyllactic acid, dl-O-acetyl-3-phenyllactic acid and (±)-mexiletine acetamide enantiomers},
journal = {Talanta},
year = {2008},
volume = {75},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/j.talanta.2007.11.004},
number = {1},
pages = {239--245},
doi = {10.1016/j.talanta.2007.11.004}
}
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MLA
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Tekewe, A.. “Development and validation of HPLC method for the resolution of drug intermediates: dl-3-Phenyllactic acid, dl-O-acetyl-3-phenyllactic acid and (±)-mexiletine acetamide enantiomers.” Talanta, vol. 75, no. 1, Mar. 2008, pp. 239-245. https://doi.org/10.1016/j.talanta.2007.11.004.