Talanta, volume 194, pages 501-506

A new substrate for glutathione reductase: Glutathione coated Ag2S quantum dots

Duygu Aydemir ¹

Mahshid Hashemkhani ^{2, 3, 4}

Emek G. Durmusoglu ⁵

H. Yagci Acar ⁶

Nuray N. Ulusu ¹

Hide authors affiliations Show authors affiliations: 6 affiliations

Koc University, School of Medicine, Department of Medical Biochemistry, Sariyer 34450, Istanbul, Turkey. |

Materials Science and Engineering

Koc University |

⁴

Sariyer-34450 Istanbul Turkey |

⁵

Department of Chemistry, Koç University, Sariyer, 34450 Istanbul, Turkey |

⁶

Surface Science and Technology Center (KUYTAM) Koc University Sariyer‐34450 Istanbul Turkey |

Publication type: Journal Article

Publication date: 2019-03-01

Elsevier

Journal: Talanta

Quartile SCImago

Quartile WOS

Impact factor: 6.1

ISSN: 00399140, 18733573

DOI: 10.1016/j.talanta.2018.10.049

Copy DOI

Analytical Chemistry

Abstract

Glutathione (GSH), a key player in various cellular processes including detoxification, anti-oxidant defense system and cell proliferation is also a potentially good coating material for luminescent quantum dots. GSH is oxidized to oxidized glutathione (GSSG) under oxidative stress and then reduced back by glutathione reductase (GR) enzyme to maintain the balance of GSH/GSSG ratio. In this frame, GSH stabilized quantum dots (QDs) have never been evaluated as GR substrate. Here, GSH coated Ag2S QDs, luminescent in the medical window, were prepared and their GR activity were tested. We have shown by spectrophotometric methods that GSH-Ag2S acted as a substrate-analog for GR enzyme that had lower activity compared to the original substrate GSSG. These results provide a new perspective in the evaluation of QDs in medical applications, enzyme activity or level detection as well as possible means to study enzymes.

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	2 4 6 8 10 12 14

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Aydemir D. et al. A new substrate for glutathione reductase: Glutathione coated Ag2S quantum dots // Talanta. 2019. Vol. 194. pp. 501-506.

GOST all authors (up to 50) Copy

Aydemir D., Hashemkhani M., Durmusoglu E. G., Acar H. Y., Ulusu N. A new substrate for glutathione reductase: Glutathione coated Ag2S quantum dots // Talanta. 2019. Vol. 194. pp. 501-506.

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RIS Copy

TY - JOUR

DO - 10.1016/j.talanta.2018.10.049

UR - https://doi.org/10.1016/j.talanta.2018.10.049

TI - A new substrate for glutathione reductase: Glutathione coated Ag2S quantum dots

T2 - Talanta

AU - Aydemir, Duygu

AU - Hashemkhani, Mahshid

AU - Durmusoglu, Emek G.

AU - Acar, H. Yagci

AU - Ulusu, Nuray N.

PY - 2019

DA - 2019/03/01 00:00:00

PB - Elsevier

SP - 501-506

VL - 194

SN - 0039-9140

SN - 1873-3573

ER -

BibTex

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BibTex Copy

@article{2019_Aydemir,

author = {Duygu Aydemir and Mahshid Hashemkhani and Emek G. Durmusoglu and H. Yagci Acar and Nuray N. Ulusu},

title = {A new substrate for glutathione reductase: Glutathione coated Ag2S quantum dots},

journal = {Talanta},

year = {2019},

volume = {194},

publisher = {Elsevier},

month = {mar},

url = {https://doi.org/10.1016/j.talanta.2018.10.049},

pages = {501--506},

doi = {10.1016/j.talanta.2018.10.049}

}

Found error?

Publisher

Elsevier

Journal

Talanta

Quartile SCImago

Quartile WOS

Impact factor

6.1

ISSN

00399140 (Print)
18733573 (Electronic)