Development of a practical synthesis of novel, pyrrole-based HMG-CoA reductase inhibitors
Jeffrey A Pfefferkorn
1
,
Daniel M Bowles
1
,
William Kissel
1
,
David C. Boyles
1
,
Chulho Choi
1
,
Scott D. Larsen
1
,
Yuntao Song
1
,
Kuai-Lin Sun
1
,
Steven B. Miller
1
,
Bharat K Trivedi
1
1
Pfizer Global Research and Development , 2800 Plymouth Road, Ann Arbor, MI, 48105, USA
|
Publication type: Journal Article
Publication date: 2007-08-01
scimago Q3
wos Q2
SJR: 0.426
CiteScore: 4.1
Impact factor: 2.2
ISSN: 00404020, 14645416
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
This paper describes the development of an efficient and scalable second generation synthesis of novel, pyrrole-based HMG-CoA reductase inhibitors. Compound 1 was identified as part of a discovery program aimed at finding improved treatments for hypercholesterolemia. Herein, we describe an efficient synthesis of its highly functionalized pyrrole core followed by attachment of the 3,5-dihydroxyhexanoic acid side chain via ylide olefination chemistry.
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27
Total citations:
27
Citations from 2025:
2
(7.41%)
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MLA
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GOST
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Pfefferkorn J. A. et al. Development of a practical synthesis of novel, pyrrole-based HMG-CoA reductase inhibitors // Tetrahedron. 2007. Vol. 63. No. 34. pp. 8124-8134.
GOST all authors (up to 50)
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Pfefferkorn J. A., Bowles D. M., Kissel W., Boyles D. C., Choi C., Larsen S. D., Song Y., Sun K., Miller S. B., Trivedi B. K. Development of a practical synthesis of novel, pyrrole-based HMG-CoA reductase inhibitors // Tetrahedron. 2007. Vol. 63. No. 34. pp. 8124-8134.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.tet.2007.06.005
UR - https://doi.org/10.1016/j.tet.2007.06.005
TI - Development of a practical synthesis of novel, pyrrole-based HMG-CoA reductase inhibitors
T2 - Tetrahedron
AU - Pfefferkorn, Jeffrey A
AU - Bowles, Daniel M
AU - Kissel, William
AU - Boyles, David C.
AU - Choi, Chulho
AU - Larsen, Scott D.
AU - Song, Yuntao
AU - Sun, Kuai-Lin
AU - Miller, Steven B.
AU - Trivedi, Bharat K
PY - 2007
DA - 2007/08/01
PB - Elsevier
SP - 8124-8134
IS - 34
VL - 63
SN - 0040-4020
SN - 1464-5416
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2007_Pfefferkorn,
author = {Jeffrey A Pfefferkorn and Daniel M Bowles and William Kissel and David C. Boyles and Chulho Choi and Scott D. Larsen and Yuntao Song and Kuai-Lin Sun and Steven B. Miller and Bharat K Trivedi},
title = {Development of a practical synthesis of novel, pyrrole-based HMG-CoA reductase inhibitors},
journal = {Tetrahedron},
year = {2007},
volume = {63},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.tet.2007.06.005},
number = {34},
pages = {8124--8134},
doi = {10.1016/j.tet.2007.06.005}
}
Cite this
MLA
Copy
Pfefferkorn, Jeffrey A., et al. “Development of a practical synthesis of novel, pyrrole-based HMG-CoA reductase inhibitors.” Tetrahedron, vol. 63, no. 34, Aug. 2007, pp. 8124-8134. https://doi.org/10.1016/j.tet.2007.06.005.