Highly enantioselective Biginelli reaction catalyzed by a simple chiral primary amine catalyst: asymmetric synthesis of dihydropyrimidines
Publication type: Journal Article
Publication date: 2012-09-01
scimago Q3
wos Q2
SJR: 0.426
CiteScore: 4.1
Impact factor: 2.2
ISSN: 00404020, 14645416
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
Several chiral primary amines were introduced as organocatalysts for the asymmetric Biginelli reaction. The reaction was performed by using a combined catalyst consisting of a chiral bifunctional primary amine–pyridine 5j and hydrochloric acid in a mixed solvent of 1,4-dioxane/CHCl 3 (8/2, v/v) at room temperature. The corresponding dihydropyrimidines were obtained in moderate to high yields with up to >99% ee under mild conditions.
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65
Total citations:
65
Citations from 2024:
8
(12.31%)
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GOST
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Xu D., Li H., Wang Y. Highly enantioselective Biginelli reaction catalyzed by a simple chiral primary amine catalyst: asymmetric synthesis of dihydropyrimidines // Tetrahedron. 2012. Vol. 68. No. 38. pp. 7867-7872.
GOST all authors (up to 50)
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Xu D., Li H., Wang Y. Highly enantioselective Biginelli reaction catalyzed by a simple chiral primary amine catalyst: asymmetric synthesis of dihydropyrimidines // Tetrahedron. 2012. Vol. 68. No. 38. pp. 7867-7872.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.tet.2012.07.027
UR - https://doi.org/10.1016/j.tet.2012.07.027
TI - Highly enantioselective Biginelli reaction catalyzed by a simple chiral primary amine catalyst: asymmetric synthesis of dihydropyrimidines
T2 - Tetrahedron
AU - Xu, Dazhen
AU - Li, Hui
AU - Wang, Yongmei
PY - 2012
DA - 2012/09/01
PB - Elsevier
SP - 7867-7872
IS - 38
VL - 68
SN - 0040-4020
SN - 1464-5416
ER -
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BibTex (up to 50 authors)
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@article{2012_Xu,
author = {Dazhen Xu and Hui Li and Yongmei Wang},
title = {Highly enantioselective Biginelli reaction catalyzed by a simple chiral primary amine catalyst: asymmetric synthesis of dihydropyrimidines},
journal = {Tetrahedron},
year = {2012},
volume = {68},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/j.tet.2012.07.027},
number = {38},
pages = {7867--7872},
doi = {10.1016/j.tet.2012.07.027}
}
Cite this
MLA
Copy
Xu, Dazhen, et al. “Highly enantioselective Biginelli reaction catalyzed by a simple chiral primary amine catalyst: asymmetric synthesis of dihydropyrimidines.” Tetrahedron, vol. 68, no. 38, Sep. 2012, pp. 7867-7872. https://doi.org/10.1016/j.tet.2012.07.027.