CuBr2-catalyzed alkylation of furans with benzyl alcohols and benzaldehydes. Domino reactions including this alkylation as a key step
Anton S Makarov
1
,
Anna E Kekhvaeva
1
,
Christopher J J Hall
2
,
Daniel J. Price
2
,
Igor V Trushkov
3
,
Publication type: Journal Article
Publication date: 2017-12-01
scimago Q3
wos Q2
SJR: 0.426
CiteScore: 4.1
Impact factor: 2.2
ISSN: 00404020, 14645416
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
A CuBr2-catalyzed alkylation of furans with a broad scope of benzyl alcohols and benzaldehydes is reported. Reaction proceeds efficiently under mild reaction conditions requiring no inert atmosphere or other precautions. Moreover, it is shown that CuBr2 catalyzes domino reactions of furans with benzyl alcohols or benzaldehydes bearing a nucleophilic moiety in the ortho-position. These protocols offer a practical approach to densely substituted heterocyclic motifs from easily available furans.
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15
Total citations:
15
Citations from 2025:
2
(13.33%)
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GOST
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Makarov A. S. et al. CuBr2-catalyzed alkylation of furans with benzyl alcohols and benzaldehydes. Domino reactions including this alkylation as a key step // Tetrahedron. 2017. Vol. 73. No. 50. pp. 7042-7053.
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Makarov A. S., Kekhvaeva A. E., Hall C. J. J., Price D. J., Trushkov I. V., Uchuskin M. G. CuBr2-catalyzed alkylation of furans with benzyl alcohols and benzaldehydes. Domino reactions including this alkylation as a key step // Tetrahedron. 2017. Vol. 73. No. 50. pp. 7042-7053.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.tet.2017.10.054
UR - https://doi.org/10.1016/j.tet.2017.10.054
TI - CuBr2-catalyzed alkylation of furans with benzyl alcohols and benzaldehydes. Domino reactions including this alkylation as a key step
T2 - Tetrahedron
AU - Makarov, Anton S
AU - Kekhvaeva, Anna E
AU - Hall, Christopher J J
AU - Price, Daniel J.
AU - Trushkov, Igor V
AU - Uchuskin, Maxim G
PY - 2017
DA - 2017/12/01
PB - Elsevier
SP - 7042-7053
IS - 50
VL - 73
SN - 0040-4020
SN - 1464-5416
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2017_Makarov,
author = {Anton S Makarov and Anna E Kekhvaeva and Christopher J J Hall and Daniel J. Price and Igor V Trushkov and Maxim G Uchuskin},
title = {CuBr2-catalyzed alkylation of furans with benzyl alcohols and benzaldehydes. Domino reactions including this alkylation as a key step},
journal = {Tetrahedron},
year = {2017},
volume = {73},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.tet.2017.10.054},
number = {50},
pages = {7042--7053},
doi = {10.1016/j.tet.2017.10.054}
}
Cite this
MLA
Copy
Makarov, Anton S., et al. “CuBr2-catalyzed alkylation of furans with benzyl alcohols and benzaldehydes. Domino reactions including this alkylation as a key step.” Tetrahedron, vol. 73, no. 50, Dec. 2017, pp. 7042-7053. https://doi.org/10.1016/j.tet.2017.10.054.
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