, volume 51 , issue 12 , pages 1533-1536

Catalyzing the Erlenmeyer Plöchl reaction: organic bases versus sodium acetate

THOMAS G. CLEARY ¹

Thimma Rawalpally ¹

Nicole Kennedy ¹

Flavio Chávez ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Pharmaceutical Technical Development Actives (PTDA-FL), Roche Carolina Inc., 6173 East Old Marion Highway, Florence, SC 29506 9330, USA |

Publication type: Journal Article

Publication date: 2010-03-01

Elsevier

Tetrahedron Letters

scimago Q3

wos Q3

SJR: 0.334

CiteScore: 3.2

Impact factor: 1.5

ISSN: 00404039, 18733581

DOI: 10.1016/j.tetlet.2009.11.125

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Organic Chemistry

Drug Discovery

Biochemistry

Abstract

An evaluation of organic base versus sodium acetate as the base in the Erlenmeyer Plochl reaction was performed. Aldehyde substituents play an important role in these reactions. Organic bases afford fast reactions, but other side reactions were observed. Alternatively, in the presence of solvent, sodium acetate could be used in catalytic amounts rather than the typical stoichiometric quantities. This Letter reports the comparative results for the use of organic bases versus sodium acetate in Erlenmeyer Plochl reactions.

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Vereshchagin Anatoly

DSc in Chemistry

163 publications, 2 730 citations, 8 reviews

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N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

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CLEARY T. G. et al. Catalyzing the Erlenmeyer Plöchl reaction: organic bases versus sodium acetate // Tetrahedron Letters. 2010. Vol. 51. No. 12. pp. 1533-1536.

GOST all authors (up to 50) Copy

CLEARY T. G., Rawalpally T., Kennedy N., Chávez F. Catalyzing the Erlenmeyer Plöchl reaction: organic bases versus sodium acetate // Tetrahedron Letters. 2010. Vol. 51. No. 12. pp. 1533-1536.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.tetlet.2009.11.125

UR - https://doi.org/10.1016/j.tetlet.2009.11.125

TI - Catalyzing the Erlenmeyer Plöchl reaction: organic bases versus sodium acetate

T2 - Tetrahedron Letters

AU - CLEARY, THOMAS G.

AU - Rawalpally, Thimma

AU - Kennedy, Nicole

AU - Chávez, Flavio

PY - 2010

DA - 2010/03/01

PB - Elsevier

SP - 1533-1536

IS - 12

VL - 51

SN - 0040-4039

SN - 1873-3581

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2010_CLEARY,

author = {THOMAS G. CLEARY and Thimma Rawalpally and Nicole Kennedy and Flavio Chávez},

title = {Catalyzing the Erlenmeyer Plöchl reaction: organic bases versus sodium acetate},

journal = {Tetrahedron Letters},

year = {2010},

volume = {51},

publisher = {Elsevier},

month = {mar},

url = {https://doi.org/10.1016/j.tetlet.2009.11.125},

number = {12},

pages = {1533--1536},

doi = {10.1016/j.tetlet.2009.11.125}

}

MLA

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MLA Copy

CLEARY, THOMAS G., et al. “Catalyzing the Erlenmeyer Plöchl reaction: organic bases versus sodium acetate.” Tetrahedron Letters, vol. 51, no. 12, Mar. 2010, pp. 1533-1536. https://doi.org/10.1016/j.tetlet.2009.11.125.

Publisher

Elsevier

Journal

Tetrahedron Letters

scimago Q3

wos Q3

SJR

0.334

CiteScore

3.2

Impact factor

1.5

ISSN

00404039 (Print)

18733581 (Electronic)