An efficient synthesis of daidzein, dimethyldaidzein, and isoformononetin
1
Department of Chemistry, Biochemistry, and Physics, Niagara University, NY 14109, USA.
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Publication type: Journal Article
Publication date: 2010-08-01
scimago Q3
wos Q3
SJR: 0.334
CiteScore: 3.2
Impact factor: 1.5
ISSN: 00404039, 18733581
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
Synthesis of the soy isoflavone, daidzein, and its derivatives, isoformononetin and dimethyldaidzein, through utilization of a novel synthetic pathway is reported. This synthesis employs an enamine addition and O-methylation of 2,4-dihydroxyacetophenone, a subsequent ring closure and iodination, followed by a Suzuki coupling with PEG 10000. Demethylation of either isoformononetin or dimethyldaidzein afforded daidzein.
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Total citations:
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Citations from 2025:
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(4.76%)
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GOST
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Biegasiewicz K. F. et al. An efficient synthesis of daidzein, dimethyldaidzein, and isoformononetin // Tetrahedron Letters. 2010. Vol. 51. No. 33. pp. 4408-4410.
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Biegasiewicz K. F., Denis J. D. S., Carroll V. M., Priefer R. An efficient synthesis of daidzein, dimethyldaidzein, and isoformononetin // Tetrahedron Letters. 2010. Vol. 51. No. 33. pp. 4408-4410.
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RIS
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TY - JOUR
DO - 10.1016/j.tetlet.2010.06.078
UR - https://doi.org/10.1016/j.tetlet.2010.06.078
TI - An efficient synthesis of daidzein, dimethyldaidzein, and isoformononetin
T2 - Tetrahedron Letters
AU - Biegasiewicz, Kyle F
AU - Denis, Jeffrey D St
AU - Carroll, Vincent M.
AU - Priefer, Ronny
PY - 2010
DA - 2010/08/01
PB - Elsevier
SP - 4408-4410
IS - 33
VL - 51
SN - 0040-4039
SN - 1873-3581
ER -
Cite this
BibTex (up to 50 authors)
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@article{2010_Biegasiewicz,
author = {Kyle F Biegasiewicz and Jeffrey D St Denis and Vincent M. Carroll and Ronny Priefer},
title = {An efficient synthesis of daidzein, dimethyldaidzein, and isoformononetin},
journal = {Tetrahedron Letters},
year = {2010},
volume = {51},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.tetlet.2010.06.078},
number = {33},
pages = {4408--4410},
doi = {10.1016/j.tetlet.2010.06.078}
}
Cite this
MLA
Copy
Biegasiewicz, Kyle F., et al. “An efficient synthesis of daidzein, dimethyldaidzein, and isoformononetin.” Tetrahedron Letters, vol. 51, no. 33, Aug. 2010, pp. 4408-4410. https://doi.org/10.1016/j.tetlet.2010.06.078.