Cascade assembly of N,N′-dialkylbarbituric acids and aldehydes: a simple and efficient one-pot approach to the substituted 1,5-dihydro-2H,2′H-spiro(furo[2,3-d]pyrimidine-6,5′-pyrimidine)-2,2′,4,4′,6′(1′H,3H,3′H)-pentone framework
Publication type: Journal Article
Publication date: 2010-12-01
scimago Q3
wos Q3
SJR: 0.334
CiteScore: 3.2
Impact factor: 1.5
ISSN: 00404039, 18733581
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
Cascade assembly of N , N ′-dialkylbarbituric acids and aldehydes in the presence of bromine leads to the selective and efficient formation of substituted 1,5-dihydro-2 H ,2′ H -spiro(furo[2,3- d ]pyrimidine-6,5′-pyrimidine)-2,2′,4,4′,6′-(1′ H ,3 H ,3′ H )-pentones in 70–88% yields via a complex cascade process. Spirobarbiturates containing the furo[2,3- d ]pyrimidine framework are a class of compounds with interesting pharmacological and physiological activity.
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Total citations:
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Citations from 2025:
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(5.41%)
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Elinson M. N. et al. Cascade assembly of N,N′-dialkylbarbituric acids and aldehydes: a simple and efficient one-pot approach to the substituted 1,5-dihydro-2H,2′H-spiro(furo[2,3-d]pyrimidine-6,5′-pyrimidine)-2,2′,4,4′,6′(1′H,3H,3′H)-pentone framework // Tetrahedron Letters. 2010. Vol. 51. No. 50. pp. 6598-6601.
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Elinson M. N., Vereshchagin A. N., Stepanov N., Belyakov P. A., Nikishin G. I. Cascade assembly of N,N′-dialkylbarbituric acids and aldehydes: a simple and efficient one-pot approach to the substituted 1,5-dihydro-2H,2′H-spiro(furo[2,3-d]pyrimidine-6,5′-pyrimidine)-2,2′,4,4′,6′(1′H,3H,3′H)-pentone framework // Tetrahedron Letters. 2010. Vol. 51. No. 50. pp. 6598-6601.
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TY - JOUR
DO - 10.1016/j.tetlet.2010.10.041
UR - https://doi.org/10.1016/j.tetlet.2010.10.041
TI - Cascade assembly of N,N′-dialkylbarbituric acids and aldehydes: a simple and efficient one-pot approach to the substituted 1,5-dihydro-2H,2′H-spiro(furo[2,3-d]pyrimidine-6,5′-pyrimidine)-2,2′,4,4′,6′(1′H,3H,3′H)-pentone framework
T2 - Tetrahedron Letters
AU - Elinson, M. N.
AU - Vereshchagin, Anatolii N.
AU - Stepanov, Nikita
AU - Belyakov, Pavel A
AU - Nikishin, Gennady I.
PY - 2010
DA - 2010/12/01
PB - Elsevier
SP - 6598-6601
IS - 50
VL - 51
SN - 0040-4039
SN - 1873-3581
ER -
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@article{2010_Elinson,
author = {M. N. Elinson and Anatolii N. Vereshchagin and Nikita Stepanov and Pavel A Belyakov and Gennady I. Nikishin},
title = {Cascade assembly of N,N′-dialkylbarbituric acids and aldehydes: a simple and efficient one-pot approach to the substituted 1,5-dihydro-2H,2′H-spiro(furo[2,3-d]pyrimidine-6,5′-pyrimidine)-2,2′,4,4′,6′(1′H,3H,3′H)-pentone framework},
journal = {Tetrahedron Letters},
year = {2010},
volume = {51},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.tetlet.2010.10.041},
number = {50},
pages = {6598--6601},
doi = {10.1016/j.tetlet.2010.10.041}
}
Cite this
MLA
Copy
Elinson, M. N., et al. “Cascade assembly of N,N′-dialkylbarbituric acids and aldehydes: a simple and efficient one-pot approach to the substituted 1,5-dihydro-2H,2′H-spiro(furo[2,3-d]pyrimidine-6,5′-pyrimidine)-2,2′,4,4′,6′(1′H,3H,3′H)-pentone framework.” Tetrahedron Letters, vol. 51, no. 50, Dec. 2010, pp. 6598-6601. https://doi.org/10.1016/j.tetlet.2010.10.041.
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