Synthesis and antimalarial activity of new 1,2,4,5-tetroxanes and novel alkoxy-substituted 1,2,4,5-tetroxanes derived from primary gem-dihydroperoxides
Тип публикации: Journal Article
Дата публикации: 2011-01-01
scimago Q3
wos Q3
БС2
SJR: 0.334
CiteScore: 3.2
Impact factor: 1.5
ISSN: 00404039, 18733581
Organic Chemistry
Drug Discovery
Biochemistry
Краткое описание
A convenient synthesis of new unsymmetrically substituted 1,2,4,5-tetroxanes and novel unsymmetrical alkoxy-substituted 1,2,4,5-tetroxanes starting from primary dihydroperoxides was developed. The structure of some tetroxanes was unambiguously assigned by X-ray crystal analysis giving interesting insights in the configuration and conformation of disubstituted 1,2,4,5-tetroxanes. Some of these tetroxanes showed notable antimalarial activity in vitro.
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Hamann H. J. et al. Synthesis and antimalarial activity of new 1,2,4,5-tetroxanes and novel alkoxy-substituted 1,2,4,5-tetroxanes derived from primary gem-dihydroperoxides // Tetrahedron Letters. 2011. Vol. 52. No. 1. pp. 107-111.
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Hamann H. J., Hecht M., Bunge A., Gogol M., Liebscher J. Synthesis and antimalarial activity of new 1,2,4,5-tetroxanes and novel alkoxy-substituted 1,2,4,5-tetroxanes derived from primary gem-dihydroperoxides // Tetrahedron Letters. 2011. Vol. 52. No. 1. pp. 107-111.
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TY - JOUR
DO - 10.1016/j.tetlet.2010.10.151
UR - https://doi.org/10.1016/j.tetlet.2010.10.151
TI - Synthesis and antimalarial activity of new 1,2,4,5-tetroxanes and novel alkoxy-substituted 1,2,4,5-tetroxanes derived from primary gem-dihydroperoxides
T2 - Tetrahedron Letters
AU - Hamann, Hans Jürgen
AU - Hecht, Mandy
AU - Bunge, Alexander
AU - Gogol, Malgorzata
AU - Liebscher, Jürgen
PY - 2011
DA - 2011/01/01
PB - Elsevier
SP - 107-111
IS - 1
VL - 52
SN - 0040-4039
SN - 1873-3581
ER -
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@article{2011_Hamann,
author = {Hans Jürgen Hamann and Mandy Hecht and Alexander Bunge and Malgorzata Gogol and Jürgen Liebscher},
title = {Synthesis and antimalarial activity of new 1,2,4,5-tetroxanes and novel alkoxy-substituted 1,2,4,5-tetroxanes derived from primary gem-dihydroperoxides},
journal = {Tetrahedron Letters},
year = {2011},
volume = {52},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.tetlet.2010.10.151},
number = {1},
pages = {107--111},
doi = {10.1016/j.tetlet.2010.10.151}
}
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Hamann, Hans Jürgen, et al. “Synthesis and antimalarial activity of new 1,2,4,5-tetroxanes and novel alkoxy-substituted 1,2,4,5-tetroxanes derived from primary gem-dihydroperoxides.” Tetrahedron Letters, vol. 52, no. 1, Jan. 2011, pp. 107-111. https://doi.org/10.1016/j.tetlet.2010.10.151.