Development of a general approach to the synthesis of a library of isoflavonoid derivatives
1
Department of Chemistry, Biochemistry, and Physics, Niagara University, NY 14109, USA.
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2
College of Pharmacy, Western New England University, Springfield, MA 01119, USA.
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3
College of Pharmacy, Western New England University, Springfield, MA 01119, USA
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4
Department of Chemistry, Biochemistry, and Physics, Niagara University, NY 14109, USA
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Publication type: Journal Article
Publication date: 2014-09-01
scimago Q3
wos Q3
SJR: 0.334
CiteScore: 3.2
Impact factor: 1.5
ISSN: 00404039, 18733581
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
Isoflavonoids are a class of organic compounds that act primarily as antioxidants. They are produced almost exclusively by various members of the bean family including soybeans, tofu, peanuts, chick peas, and alfalfa. The antioxidant characteristics that isoflavonoids exhibit help hinder the progression of certain cancers, primarily breast, prostate, and colon cancer. We have developed a three-five step synthesis for obtaining a suite of isoflavonoid derivatives. The synthesis involves an enamine formation, a ring closure and halogenation, a Suzuki coupling, and finally a global deprotection to obtain the respective isoflavonoid derivatives.
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Biegasiewicz K. F. et al. Development of a general approach to the synthesis of a library of isoflavonoid derivatives // Tetrahedron Letters. 2014. Vol. 55. No. 37. pp. 5210-5212.
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Biegasiewicz K. F., Gordon J. S., Rodriguez D. A., Priefer R. Development of a general approach to the synthesis of a library of isoflavonoid derivatives // Tetrahedron Letters. 2014. Vol. 55. No. 37. pp. 5210-5212.
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TY - JOUR
DO - 10.1016/j.tetlet.2014.07.110
UR - https://doi.org/10.1016/j.tetlet.2014.07.110
TI - Development of a general approach to the synthesis of a library of isoflavonoid derivatives
T2 - Tetrahedron Letters
AU - Biegasiewicz, Kyle F
AU - Gordon, James S.
AU - Rodriguez, Deana A
AU - Priefer, Ronny
PY - 2014
DA - 2014/09/01
PB - Elsevier
SP - 5210-5212
IS - 37
VL - 55
SN - 0040-4039
SN - 1873-3581
ER -
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BibTex (up to 50 authors)
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@article{2014_Biegasiewicz,
author = {Kyle F Biegasiewicz and James S. Gordon and Deana A Rodriguez and Ronny Priefer},
title = {Development of a general approach to the synthesis of a library of isoflavonoid derivatives},
journal = {Tetrahedron Letters},
year = {2014},
volume = {55},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/j.tetlet.2014.07.110},
number = {37},
pages = {5210--5212},
doi = {10.1016/j.tetlet.2014.07.110}
}
Cite this
MLA
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Biegasiewicz, Kyle F., et al. “Development of a general approach to the synthesis of a library of isoflavonoid derivatives.” Tetrahedron Letters, vol. 55, no. 37, Sep. 2014, pp. 5210-5212. https://doi.org/10.1016/j.tetlet.2014.07.110.