Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog
Rosana Leiva
1
,
Sabrina Gazzarrini
2
,
Roser Esplugas
3
,
Anna Moroni
2
,
Lieve Naesens
4
,
F. X. Sureda
3
,
1
Publication type: Journal Article
Publication date: 2015-03-01
scimago Q3
wos Q3
SJR: 0.334
CiteScore: 3.2
Impact factor: 1.5
ISSN: 00404039, 18733581
PubMed ID:
32287445
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
Two alternative syntheses of 2-oxaadamantan-5-amine, a novel analog of the clinically approved drug amantadine, are reported. The compound has been tested as an anti-influenza A virus agent and as an NMDA receptor antagonist. While the compound was not antivirally active, it displayed moderate activity as an NMDA receptor antagonist.
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Total citations:
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Citations from 2024:
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(38.46%)
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GOST
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Leiva R. et al. Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog // Tetrahedron Letters. 2015. Vol. 56. No. 10. pp. 1272-1275.
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Leiva R., Gazzarrini S., Esplugas R., Moroni A., Naesens L., Sureda F. X., Vazquez S. Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog // Tetrahedron Letters. 2015. Vol. 56. No. 10. pp. 1272-1275.
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RIS
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TY - JOUR
DO - 10.1016/j.tetlet.2015.01.160
UR - https://doi.org/10.1016/j.tetlet.2015.01.160
TI - Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog
T2 - Tetrahedron Letters
AU - Leiva, Rosana
AU - Gazzarrini, Sabrina
AU - Esplugas, Roser
AU - Moroni, Anna
AU - Naesens, Lieve
AU - Sureda, F. X.
AU - Vazquez, Santiago
PY - 2015
DA - 2015/03/01
PB - Elsevier
SP - 1272-1275
IS - 10
VL - 56
PMID - 32287445
SN - 0040-4039
SN - 1873-3581
ER -
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BibTex (up to 50 authors)
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@article{2015_Leiva,
author = {Rosana Leiva and Sabrina Gazzarrini and Roser Esplugas and Anna Moroni and Lieve Naesens and F. X. Sureda and Santiago Vazquez},
title = {Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog},
journal = {Tetrahedron Letters},
year = {2015},
volume = {56},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/j.tetlet.2015.01.160},
number = {10},
pages = {1272--1275},
doi = {10.1016/j.tetlet.2015.01.160}
}
Cite this
MLA
Copy
Leiva, Rosana, et al. “Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog.” Tetrahedron Letters, vol. 56, no. 10, Mar. 2015, pp. 1272-1275. https://doi.org/10.1016/j.tetlet.2015.01.160.