Spirocyclic amino alcohol building blocks prepared via a Prins-type cyclization in aqueous sulfuric acid
Publication type: Journal Article
Publication date: 2016-07-01
scimago Q3
wos Q3
SJR: 0.334
CiteScore: 3.2
Impact factor: 1.5
ISSN: 00404039, 18733581
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
A convenient Prins cyclization of various azacycloalkanones with homoallylic alcohol was achieved in aqueous sulfuric acid. The formal four-center, three-component reaction provides a facile and flexible entry into a range of spirocyclic amino alcohols which are valuable, ‘high-Fsp3’ motifs for drug design.
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15
Total citations:
15
Citations from 2025:
3
(20%)
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MLA
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GOST
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Lukin A. et al. Spirocyclic amino alcohol building blocks prepared via a Prins-type cyclization in aqueous sulfuric acid // Tetrahedron Letters. 2016. Vol. 57. No. 30. pp. 3311-3314.
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Lukin A., Bagnyukova D., Kalinchenkova N., Zhurilo N., Novikov A. S. Spirocyclic amino alcohol building blocks prepared via a Prins-type cyclization in aqueous sulfuric acid // Tetrahedron Letters. 2016. Vol. 57. No. 30. pp. 3311-3314.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.tetlet.2016.06.054
UR - https://doi.org/10.1016/j.tetlet.2016.06.054
TI - Spirocyclic amino alcohol building blocks prepared via a Prins-type cyclization in aqueous sulfuric acid
T2 - Tetrahedron Letters
AU - Lukin, Alexey
AU - Bagnyukova, Darya
AU - Kalinchenkova, Natalya
AU - Zhurilo, Nikolay
AU - Novikov, Alexander S.
PY - 2016
DA - 2016/07/01
PB - Elsevier
SP - 3311-3314
IS - 30
VL - 57
SN - 0040-4039
SN - 1873-3581
ER -
Cite this
BibTex (up to 50 authors)
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@article{2016_Lukin,
author = {Alexey Lukin and Darya Bagnyukova and Natalya Kalinchenkova and Nikolay Zhurilo and Alexander S. Novikov},
title = {Spirocyclic amino alcohol building blocks prepared via a Prins-type cyclization in aqueous sulfuric acid},
journal = {Tetrahedron Letters},
year = {2016},
volume = {57},
publisher = {Elsevier},
month = {jul},
url = {https://doi.org/10.1016/j.tetlet.2016.06.054},
number = {30},
pages = {3311--3314},
doi = {10.1016/j.tetlet.2016.06.054}
}
Cite this
MLA
Copy
Lukin, Alexey, et al. “Spirocyclic amino alcohol building blocks prepared via a Prins-type cyclization in aqueous sulfuric acid.” Tetrahedron Letters, vol. 57, no. 30, Jul. 2016, pp. 3311-3314. https://doi.org/10.1016/j.tetlet.2016.06.054.