Elsevier
Tetrahedron Letters
,  том 61 ,  издание 45 ,  страницы 152490

Synthesis of 1,2,4-triazolo[5′,1′:2,3][1,3]thiazino[6,5-b]indol-10(5H)-ones based on 2-chloro-1H-indole-3-carbaldehyde

Тип публикации: Journal Article
Дата публикации: 2020-11-01
Elsevier
scimago Q3
wos Q3
БС2
SJR: 0.334
CiteScore: 3.2
Impact factor: 1.5
ISSN: 00404039, 18733581
Organic Chemistry
Drug Discovery
Biochemistry
Краткое описание
Abstract As a result of the reaction of 2-chloro-1H-indole-3-carbaldehydes with 4-amino-5-alkyl-4H-1,2,4-triazole-3-thiols in DMF, representatives of a new heterocyclic system, 1,2,4-triazolo[5′,1′:2,3][1,3]thiazino[6,5-b]indol-10(5H)-one, were obtained. The reaction proceeds unusually, with a the release of an ammonia molecule. The structure of 1,2,4-triazolo[5′,1′:2,3][1,3]thiazino[6,5-b]indol-10(5H)-ones was established by X-ray diffraction. The obtained compounds contain rutalexin scaffold in the structure and are promising in terms of biological activity.
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Vikrishchuk N. I. et al. Synthesis of 1,2,4-triazolo[5′,1′:2,3][1,3]thiazino[6,5-b]indol-10(5H)-ones based on 2-chloro-1H-indole-3-carbaldehyde // Tetrahedron Letters. 2020. Vol. 61. No. 45. p. 152490.
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Vikrishchuk N. I., Tkachev V. V., Borodkin G. S., Gazieva G. A., Shilov G. V. Synthesis of 1,2,4-triazolo[5′,1′:2,3][1,3]thiazino[6,5-b]indol-10(5H)-ones based on 2-chloro-1H-indole-3-carbaldehyde // Tetrahedron Letters. 2020. Vol. 61. No. 45. p. 152490.
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TY - JOUR
DO - 10.1016/j.tetlet.2020.152490
UR - https://linkinghub.elsevier.com/retrieve/pii/S0040403920309710
TI - Synthesis of 1,2,4-triazolo[5′,1′:2,3][1,3]thiazino[6,5-b]indol-10(5H)-ones based on 2-chloro-1H-indole-3-carbaldehyde
T2 - Tetrahedron Letters
AU - Vikrishchuk, Natalia I
AU - Tkachev, Valerii V
AU - Borodkin, Gennady S
AU - Gazieva, Galina A.
AU - Shilov, G. V.
PY - 2020
DA - 2020/11/01
PB - Elsevier
SP - 152490
IS - 45
VL - 61
SN - 0040-4039
SN - 1873-3581
ER -
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@article{2020_Vikrishchuk,
author = {Natalia I Vikrishchuk and Valerii V Tkachev and Gennady S Borodkin and Galina A. Gazieva and G. V. Shilov},
title = {Synthesis of 1,2,4-triazolo[5′,1′:2,3][1,3]thiazino[6,5-b]indol-10(5H)-ones based on 2-chloro-1H-indole-3-carbaldehyde},
journal = {Tetrahedron Letters},
year = {2020},
volume = {61},
publisher = {Elsevier},
month = {nov},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0040403920309710},
number = {45},
pages = {152490},
doi = {10.1016/j.tetlet.2020.152490}
}
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Vikrishchuk, Natalia I., et al. “Synthesis of 1,2,4-triazolo[5′,1′:2,3][1,3]thiazino[6,5-b]indol-10(5H)-ones based on 2-chloro-1H-indole-3-carbaldehyde.” Tetrahedron Letters, vol. 61, no. 45, Nov. 2020, p. 152490. https://linkinghub.elsevier.com/retrieve/pii/S0040403920309710.