volume 93 pages 153695

A multi-purpose synthetic α-amino acid featuring coumarin and ureidopyrimidinone motifs on its backbone: Synthesis and peptide formation

P P Rashid 1, 2
Gangadhar J. Sanjayan 1, 2
Publication typeJournal Article
Publication date2022-03-01
scimago Q3
wos Q3
SJR0.334
CiteScore3.2
Impact factor1.5
ISSN00404039, 18733581
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
Herein we report a synthetic α -amino acid featuring intensely fluorescent coumarin moiety and a strongly self-assembling ureidopyrimidinone (UPy) motif. This two-in-one synthetic amino acid, displaying both fluorescence and self-assembling property, has been synthesized in four easy steps starting from commercially available inexpensive starting materials. Suitably protected amino acid has been incorporated into various peptide sequences, following solution-phase peptide coupling protocols, to demonstrate its synthetic feasibility.
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Rashid P. P. et al. A multi-purpose synthetic α-amino acid featuring coumarin and ureidopyrimidinone motifs on its backbone: Synthesis and peptide formation // Tetrahedron Letters. 2022. Vol. 93. p. 153695.
GOST all authors (up to 50) Copy
Rashid P. P., Sanjayan G. J. A multi-purpose synthetic α-amino acid featuring coumarin and ureidopyrimidinone motifs on its backbone: Synthesis and peptide formation // Tetrahedron Letters. 2022. Vol. 93. p. 153695.
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RIS Copy
TY - JOUR
DO - 10.1016/j.tetlet.2022.153695
UR - https://doi.org/10.1016/j.tetlet.2022.153695
TI - A multi-purpose synthetic α-amino acid featuring coumarin and ureidopyrimidinone motifs on its backbone: Synthesis and peptide formation
T2 - Tetrahedron Letters
AU - Rashid, P P
AU - Sanjayan, Gangadhar J.
PY - 2022
DA - 2022/03/01
PB - Elsevier
SP - 153695
VL - 93
SN - 0040-4039
SN - 1873-3581
ER -
BibTex
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BibTex (up to 50 authors) Copy
@article{2022_Rashid,
author = {P P Rashid and Gangadhar J. Sanjayan},
title = {A multi-purpose synthetic α-amino acid featuring coumarin and ureidopyrimidinone motifs on its backbone: Synthesis and peptide formation},
journal = {Tetrahedron Letters},
year = {2022},
volume = {93},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/j.tetlet.2022.153695},
pages = {153695},
doi = {10.1016/j.tetlet.2022.153695}
}