Toxicology

, том 393 , страницы 1-8

N-acetyl-L-cysteine and Mn²⁺ attenuate Cd²⁺-induced disturbance of the intracellular free calcium homeostasis in cultured cerebellar granule neurons

Nickolay K. Isaev ¹

Svetlana Avilkina ²

Olga P Alexandrova ³

Marina R Kapkaeva ³

Elisaveta E Genrikhs ³

Elena V. Stelmashook ³

Sergey A. Golyshev ⁴

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M. V. Lomonosov Moscow State University, N. A. Belozersky Research Institute of Physico-Chemical Biology, Leninskye Gory, 1, b. 40, 119991, Moscow, Russia |

M.V. Lomonosov Moscow State University Biological Faculty, Moscow 119234, Russia |

Research Center of Neurology, Volokolamskoe Shosse 80, 125367, Moscow, Russia. |

⁴

M. V. Lomonosov Moscow State University, N. A. Belozersky Research Institute of Physico-Chemical Biology, Leninskye gory, 1, b. 40, 119991 Moscow, Russia. |

Тип публикации: Journal Article

Дата публикации: 2018-01-01

Elsevier

Toxicology

scimago Q1

wos Q1

БС1

SJR: 1.106

CiteScore: 8.9

Impact factor: 4.6

ISSN: 0300483X, 18793185

DOI: 10.1016/j.tox.2017.10.017

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PubMed ID: 29100878

Toxicology

Краткое описание

Cadmium is a highly toxic heavy metal that is capable of accumulating in the body via direct exposure or through the alimentary and respiratory tract, leading to neurodegeneration. In this article, we show that the application of CdCl2 (0.001-0.005mM) for 48h induced high dose-dependent death rate of cultured cerebellar granule neurons (CGNs). Unlike Trolox or vitamin E, antioxidant N-acetyl-l-cysteine (NAC, 1mM) and Mn2+ (0.0025-0.005mM) significantly protected CGNs from this toxic effect. Using Fluo-4 AM, measurements of intracellular calcium ions demonstrated that 24h-exposure to Cd2+ induced intensive increase of Fluo-4 fluorescence in neurons accompanied by mitochondria swelling. These data imply that the cadmium-induced Ca2+ increase is an important element in the death of neurons due to toxic effect of cadmium and the mechanism of protective action of manganese and NAC is mediated by the prevention of increase in calcium levels.

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Avilkina S. et al. N-acetyl-L-cysteine and Mn2+ attenuate Cd2+-induced disturbance of the intracellular free calcium homeostasis in cultured cerebellar granule neurons // Toxicology. 2018. Vol. 393. pp. 1-8.

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Isaev N. K., Avilkina S., Alexandrova O. P., Kapkaeva M. R., Genrikhs E. E., Stelmashook E. V., Golyshev S. A. N-acetyl-L-cysteine and Mn2+ attenuate Cd2+-induced disturbance of the intracellular free calcium homeostasis in cultured cerebellar granule neurons // Toxicology. 2018. Vol. 393. pp. 1-8.

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TY - JOUR

DO - 10.1016/j.tox.2017.10.017

UR - https://doi.org/10.1016/j.tox.2017.10.017

TI - N-acetyl-L-cysteine and Mn2+ attenuate Cd2+-induced disturbance of the intracellular free calcium homeostasis in cultured cerebellar granule neurons

T2 - Toxicology

AU - Isaev, Nickolay K.

AU - Avilkina, Svetlana

AU - Alexandrova, Olga P

AU - Kapkaeva, Marina R

AU - Genrikhs, Elisaveta E

AU - Stelmashook, Elena V.

AU - Golyshev, Sergey A.

PY - 2018

DA - 2018/01/01

PB - Elsevier

SP - 1-8

VL - 393

PMID - 29100878

SN - 0300-483X

SN - 1879-3185

ER -

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@article{2018_Avilkina,

author = {Nickolay K. Isaev and Svetlana Avilkina and Olga P Alexandrova and Marina R Kapkaeva and Elisaveta E Genrikhs and Elena V. Stelmashook and Sergey A. Golyshev},

title = {N-acetyl-L-cysteine and Mn2+ attenuate Cd2+-induced disturbance of the intracellular free calcium homeostasis in cultured cerebellar granule neurons},

journal = {Toxicology},

year = {2018},

volume = {393},

publisher = {Elsevier},

month = {jan},

url = {https://doi.org/10.1016/j.tox.2017.10.017},

pages = {1--8},

doi = {10.1016/j.tox.2017.10.017}

}

Издатель

Elsevier

Журнал

Toxicology

scimago Q1

wos Q1

БС1

SJR

1.106

CiteScore

8.9

Impact factor

4.6

ISSN

0300483X (Print)

18793185 (Electronic)

Профили

Голышев Сергей Александрович

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