Studies of the potential genotoxic effects of furoxans: The case of CAS 1609 and of the water-soluble analogue of CHF 2363
Silvia Balbo
1
,
Loretta Lazzarato
2
,
A Di Stilo
2
,
Roberta Fruttero
2
,
N Lombaert
3
,
M. Kirsch-Volders
3
Publication type: Journal Article
Publication date: 2008-04-01
scimago Q2
wos Q2
SJR: 0.767
CiteScore: 5.9
Impact factor: 2.9
ISSN: 03784274, 18793169
PubMed ID:
18378101
General Medicine
Toxicology
Abstract
CAS 1609 (compound 1) and CHF 2363 (compound 2) are two furoxan derivatives able to release nitric oxide (NO) under physiological conditions, and display typical NO-dependent vasodilator activity. The potential genotoxic effects of compound 1 and of the water-soluble analogue of CHF 2363 (compound 2a) were investigated. The results show that the two compounds induce genotoxic effects only at concentrations that significantly reduce cell viability. However, in the case of compound 1 this range of concentrations is one order of magnitude higher than the one leading to the beneficial effects, while in the case of compound 2a these ranges partially overlap. In both cases the release of NO plays a key role in the induction of the cytotoxic and genotoxic effects, since the non-NO-donating furazan analogues display a different toxicological profile, and since the effects were reduced in the presence of oxyhaemoglobin, a well-known NO-scavenger.
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Total citations:
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Citations from 2024:
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GOST
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Balbo S. et al. Studies of the potential genotoxic effects of furoxans: The case of CAS 1609 and of the water-soluble analogue of CHF 2363 // Toxicology Letters. 2008. Vol. 178. No. 1. pp. 44-51.
GOST all authors (up to 50)
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Balbo S., Lazzarato L., Di Stilo A., Fruttero R., Lombaert N., Kirsch-Volders M. Studies of the potential genotoxic effects of furoxans: The case of CAS 1609 and of the water-soluble analogue of CHF 2363 // Toxicology Letters. 2008. Vol. 178. No. 1. pp. 44-51.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.toxlet.2008.02.001
UR - https://doi.org/10.1016/j.toxlet.2008.02.001
TI - Studies of the potential genotoxic effects of furoxans: The case of CAS 1609 and of the water-soluble analogue of CHF 2363
T2 - Toxicology Letters
AU - Balbo, Silvia
AU - Lazzarato, Loretta
AU - Di Stilo, A
AU - Fruttero, Roberta
AU - Lombaert, N
AU - Kirsch-Volders, M.
PY - 2008
DA - 2008/04/01
PB - Elsevier
SP - 44-51
IS - 1
VL - 178
PMID - 18378101
SN - 0378-4274
SN - 1879-3169
ER -
Cite this
BibTex (up to 50 authors)
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@article{2008_Balbo,
author = {Silvia Balbo and Loretta Lazzarato and A Di Stilo and Roberta Fruttero and N Lombaert and M. Kirsch-Volders},
title = {Studies of the potential genotoxic effects of furoxans: The case of CAS 1609 and of the water-soluble analogue of CHF 2363},
journal = {Toxicology Letters},
year = {2008},
volume = {178},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/j.toxlet.2008.02.001},
number = {1},
pages = {44--51},
doi = {10.1016/j.toxlet.2008.02.001}
}
Cite this
MLA
Copy
Balbo, Silvia, et al. “Studies of the potential genotoxic effects of furoxans: The case of CAS 1609 and of the water-soluble analogue of CHF 2363.” Toxicology Letters, vol. 178, no. 1, Apr. 2008, pp. 44-51. https://doi.org/10.1016/j.toxlet.2008.02.001.